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Mycoplasmas as Host Pantropic and Specific Pathogens: Clinical Implications, Gene Transfer, Virulence Factors, and

Ali Dawood1,2,3,4, Samah Attia Algharib2,5,6, Gang Zhao1,2,4,7

  • 1The State Key Laboratory of Agricultural Microbiology, (HZAU), Wuhan, China.

Frontiers in Cellular and Infection Microbiology
|June 1, 2022
PubMed

Insights

Mycoplasmas are significant pathogens causing diseases in various hosts. This review explores their pathogenesis, challenges in control, and future strategies for managing mycoplasmosis in humans and animals.

Area of Science:

  • Veterinary Medicine
  • Microbiology
  • Pathogen Research

Background:

  • Mycoplasmas are economically important, pantropic pathogens causing diverse clinical diseases by evading host defenses.
  • Despite limited metabolic capacity, they exhibit significant undiscovered virulence and host specificity, rapidly evolving to evade immune systems.
  • Current control measures for mycoplasmosis are insufficient, highlighting a critical need for advanced research.

Purpose of the Study:

  • To provide an updated insight into mycoplasmas as pathogens.
  • To summarize progress, challenges, and future perspectives in mycoplasma research.
  • To guide the development of new strategies for controlling mycoplasmosis.

Main Methods:

  • Comprehensive literature review and analysis of existing research on mycoplasmas.
  • Examination of clinical implications, virulence factors, and genetic information transfer.
  • Exploration of nanotechnology applications, vaccination, and protective immunity.

Main Results:

  • Mycoplasmas pose significant challenges due to their adaptability and rapid evolution.
  • Existing knowledge gaps exist regarding virulence factors and effective control strategies.
  • Nanotechnology and improved vaccination present promising avenues for future control.

Conclusions:

  • Further research is crucial to understand mycoplasma pathogenesis and virulence.
  • Developing novel diagnostic and therapeutic strategies, including nanotechnology and vaccines, is essential.
  • Addressing unanswered questions will facilitate better control of mycoplasmosis in humans and animals.
Keywords:
clinical implicationsgene transfermycoplasmaspantropic pathogensvaccinationvirulence factors

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