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Related Experiment Video

Updated: Sep 21, 2025

An Immunocompetent Murine Model for Laser Interstitial Thermal Therapy of Glioblastoma
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Laser Interstitial Thermal Therapy for Cavernous Malformations: A Systematic Review.

Omid Yousefi1, Mohammadmahdi Sabahi2, James Malcolm3

  • 1Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran.

Frontiers in Surgery
|June 1, 2022
PubMed
Summary

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The efficacy and safety of poly ADP-ribose polymerase (PARP) inhibitors in patients with high-grade glioma (HGG): A systematic review and meta-analysis.

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From imaging to molecular pathways: a comprehensive narrative review of the distinctive landscape of secretory meningioma.

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Idiopathic intracranial hypertension as a rare cause of trigeminal neuralgia: A systematic review with three illustrative institutional cases.

Clinical neurology and neurosurgery·2026

Laser interstitial thermal therapy (LITT) offers a minimally invasive alternative to microsurgical resection for intracranial cavernous malformations (CMs). LITT shows comparable outcomes with fewer transient complications, though long-term effects require further study.

Area of Science:

  • Neurosurgery
  • Minimally Invasive Procedures
  • Neurological Surgery

Background:

  • Intracranial cavernous malformations (CMs) are typically treated with microsurgical resection.
  • A growing trend favors minimally invasive techniques like laser interstitial thermal therapy (LITT) for CM ablation.

Purpose of the Study:

  • To systematically review the outcomes of laser interstitial thermal therapy (LITT) for intracranial cavernous malformations (CMs).

Main Methods:

  • A systematic literature search was performed across major databases (PubMed, Scopus, Embase, Cochrane).
  • Studies reporting LITT outcomes for intracranial CMs were included, extracting patient demographics, lesion characteristics, and surgical results.

Main Results:

Keywords:
LITTcavernous malformationlaser interstitial thermal therapyneurosurgerysystematic review

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  • Six studies involving 33 patients were analyzed.
  • LITT achieved satisfactory outcomes in most patients with CMs causing epilepsy, headache, or neurological deficits.
  • Complications were predominantly transient, with one case of long-term cyst formation.

    • Conclusions:

    • LITT presents a less invasive option for CM treatment, comparable to open resection, especially for deep-seated lesions.
    • Technical challenges like thermal monitoring persist.
    • Further research with larger cohorts is necessary to fully understand LITT's long-term efficacy and safety for CMs.