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Updated: Jul 24, 2026

Development of a 68Gallium-Labeled D-Peptide PET Tracer for Imaging Programmed Death-Ligand 1 Expression
Published on: February 3, 2023
PD-L1 Crosslinking as a New Strategy of 4-1BB Agonism Immunotherapy
Fei Shu1, Salman R Punekar2, Vamsidhar Velcheti2
1Department of Pathology, New York University Grossman School of Medicine, NYU Langone Health, New York, New York.
None:
4-1BB has been considered a promising target in cancer immunotherapy for decades. Nevertheless, early 4-1BB-targeted agents demonstrated significant liver immuno-toxicity. A new wave of 4-1BB-based therapy is being developed to circumvent hepatotoxicity with a bispecific molecule that directs 4-1BB agonism to the tumor microenvironment by targeting tumor-associated immune checkpoint molecule PD-L1. See related article by Peper-Gabriel et al., p. 3387.
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