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Mussel-inspired polyurethane coating for bio-surface functionalization to enhance substrate adhesion and cell
Hao Ming1, ChenXu Tian1, Nan He1
1College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu, China.
Journal of Biomaterials Science. Polymer Edition
|June 1, 2022
Summary
Researchers developed mussel-inspired polyurethane coatings (PU-LDAs) that significantly enhance implant material adhesion and reduce inflammatory responses. These coatings improve cell adhesion and growth, showing great potential for biomedical applications.
Area of Science:
- Biomaterials Science
- Polymer Chemistry
- Surface Engineering
Background:
- Implant materials often trigger inflammatory reactions due to poor histocompatibility, leading to complications and failure.
- Surface modification is crucial for improving implant performance, but achieving both strong adhesion and biocompatibility is challenging.
- Mussel-inspired chemistry offers a promising strategy for developing advanced adhesive and biocompatible coatings.
Purpose of the Study:
- To synthesize mussel-inspired polyurethane coatings (PU-LDAs) with enhanced adhesive properties and biocompatibility.
- To investigate the effect of lysine-dopamine (LDA) content on coating adhesion and inflammatory response.
- To evaluate the potential of PU-LDAs as a universal surface modification for biomedical implants.
Main Methods:
- Polyurethane synthesis via step-growth polymerization using hexamethylene diisocyanate, polytetra-methylene-ether-glycol, lysine-dopamine (LDA), and butanediol.
- One-step coating of PU-LDAs onto various substrates including stainless steel, glass, and polypropylene.
- Adhesion assessment using a 180° peel test to quantify peel strength.
- Evaluation of inflammatory response and cell adhesion/growth characteristics.
Main Results:
- PU-LDA coatings demonstrated significantly improved adhesion to stainless steel, glass, and PP compared to coatings without LDA.
- The PU-LDA100 coating exhibited peel strengths 106.2% to 246.4% higher than the control.
- The developed PU coatings showed a reduced immune inflammatory response and enhanced cell adhesion and growth due to DOPA group interactions.
Conclusions:
- Mussel-inspired polyurethanes (PU-LDAs) offer a facile and effective method for surface modification of implant materials.
- These coatings provide a universal solution for improving implant biocompatibility and reducing inflammatory reactions.
- The enhanced adhesion and cell interaction properties make PU-LDAs highly promising for clinical biomedical implant applications.
