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Comparison of severe acute respiratory syndrome coronavirus 2 (COVID-19) vaccine side effects by age groups

Fadime Tosun1, Mehmet Bulbul2, İsmail Tosun3

  • 1Adiyaman University, Faculty of Medicine, Department of Anesthesiology and Reanimation - Adiyaman, Turkey.

Revista Da Associacao Medica Brasileira (1992)
|June 1, 2022
PubMed
Abstract

Insights

Younger adults and females experienced more side effects from inactivated COVID-19 vaccines. Monitoring vaccine side effects by age and gender is recommended for better patient outcomes.

Area of Science:

  • Immunology
  • Public Health
  • Vaccinology

Background:

  • Inactivated vaccines are widely used for severe acute respiratory syndrome coronavirus 2 (COVID-19) prevention.
  • Understanding vaccine side effect profiles across different demographics is crucial for public health strategies.

Purpose of the Study:

  • To compare the incidence and types of side effects following inactivated COVID-19 vaccination across various age groups.
  • To identify demographic factors associated with vaccine-related adverse events.

Main Methods:

  • An online survey was conducted with 411 participants aged 18-100 who received an inactivated COVID-19 vaccine.
  • Participants were stratified into four age groups: 20-35, 36-50, 51-65, and over 65 years.
  • Data on vaccine side effects, including injection site reactions and systemic symptoms, were collected and analyzed.

Main Results:

  • The 20-35 age group reported the highest incidence of side effects, while the >65 age group reported the lowest (p<0.001).
  • Common side effects included injection site pain, redness, swelling, numbness, fatigue, and headache.
  • Female gender and younger age were identified as significant risk factors for developing side effects. No severe adverse events were reported.

Conclusions:

  • Inactivated COVID-19 vaccines elicit varying side effect profiles across different age groups.
  • Targeted monitoring of vaccine side effects, considering age and gender, is advised for optimal post-vaccination surveillance.
  • Younger adults, particularly females, may require closer monitoring for potential adverse reactions.

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