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Hyaluronan network: a driving force in cancer progression.
Theodoros Karalis1, Spyros S Skandalis1
1Biochemistry, Biochemical Analysis & Matrix Pathobiology Research Group, Laboratory of Biochemistry, Department of Chemistry, University of Patras, Patras, Greece.
American Journal of Physiology. Cell Physiology
|June 1, 2022
Summary
Hyaluronan, a key extracellular matrix molecule, accumulates in cancers, correlating with poor patient outcomes. Targeting the hyaluronan system presents a promising therapeutic strategy for cancer treatment.
Area of Science:
- Extracellular matrix biology
- Cancer biology
- Molecular oncology
Background:
- Hyaluronan is a major component of the extracellular matrix, regulating cell and tissue functions.
- Aberrant accumulation of hyaluronan and its receptors is observed in various cancer types.
- Elevated hyaluronan system components in tumors are linked to adverse patient prognoses.
Purpose of the Study:
- To review the physiological roles of hyaluronan in normal tissues.
- To elucidate the involvement of hyaluronan in cancer development and progression.
- To discuss the potential of targeting the hyaluronan system as a cancer therapeutic strategy.
Main Methods:
- Literature review of hyaluronan's role in physiology and cancer.
- Analysis of studies linking hyaluronan system components to cancer outcomes.
- Discussion of therapeutic approaches targeting hyaluronan.
Main Results:
- Hyaluronan significantly influences normal physiological processes.
- Hyaluronan accumulation and altered receptor expression are hallmarks of many cancers.
- Components of the hyaluronan system are associated with poor patient prognosis in tumors.
Conclusions:
- The hyaluronan system plays a dual role in normal physiology and cancer.
- Targeting hyaluronan synthesis, degradation, or interactions offers a viable therapeutic avenue.
- Further research into hyaluronan-targeted therapies is warranted for improved cancer treatment.
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