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Related Concept Videos

Tumor Progression02:07

Tumor Progression

6.5K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
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The Tumor Microenvironment02:17

The Tumor Microenvironment

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Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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Related Experiment Video

Updated: Sep 21, 2025

Co-culture of Glioblastoma Stem-like Cells on Patterned Neurons to Study Migration and Cellular Interactions
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Co-culture of Glioblastoma Stem-like Cells on Patterned Neurons to Study Migration and Cellular Interactions

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Glioma progression is shaped by genetic evolution and microenvironment interactions.

Frederick S Varn1, Kevin C Johnson1, Jan Martinek1

  • 1The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA.

Cell
|June 1, 2022
PubMed
Summary

Understanding diffuse glioma recurrence requires analyzing genetic and cellular changes. IDH-mutant and IDH-wild-type tumors show distinct progression patterns, offering potential therapeutic targets.

Keywords:
genomicsglioblastomagliomahypermutationmacrophagesmicroenvironmentneuronssingle-cellspatial imagingtreatment resistance

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Quantitative Immunohistochemistry of the Cellular Microenvironment in Patient Glioblastoma Resections
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Last Updated: Sep 21, 2025

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Quantitative Immunohistochemistry of the Cellular Microenvironment in Patient Glioblastoma Resections
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Quantitative Immunohistochemistry of the Cellular Microenvironment in Patient Glioblastoma Resections

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Area of Science:

  • Neuro-oncology
  • Cancer Genomics
  • Tumor Microenvironment

Background:

  • Therapy resistance in diffuse glioma is a significant clinical challenge.
  • The cellular and genetic factors driving treatment resistance remain poorly understood.

Purpose of the Study:

  • To identify treatment-associated cellular and genetic alterations in recurrent diffuse gliomas.
  • To compare recurrence patterns between isocitrate dehydrogenase (IDH)-wild-type and IDH-mutant glioma subtypes.

Main Methods:

  • Analysis of RNA and/or DNA sequencing data from paired tumor samples of 304 adult patients.
  • Assessment of histological features, somatic alterations, and microenvironment interactions at recurrence.

Main Results:

  • Recurrence patterns differed based on IDH mutation status, involving histological changes, genetic alterations, and microenvironment interactions.
  • Hypermutation and CDKN2A deletions correlated with increased proliferation in both subtypes.
  • IDH-wild-type tumors showed increased invasiveness and neuronal signaling, suggesting a role in progression.
  • Mesenchymal transition was linked to myeloid cell interactions with neoplastic cells.

Conclusions:

  • Distinct recurrence phenotypes in diffuse glioma are IDH-dependent and involve cellular, genetic, and microenvironmental factors.
  • These recurrence-associated phenotypes present potential therapeutic targets for altering disease progression.