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Risk Factors Associated with Severe/Critical COVID-19 in People Living with HIV-1

Antoine Bachelard1, Aurelie Sautereau1, Marc Digumber1

  • 1AP-HP, Infectious and Tropical Diseases Department, Bichat-Claude Bernard University Hospital, Paris, France.

International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases
|June 1, 2022
PubMed

Insights

Risk factors for severe COVID-19 in people living with HIV-1 (PLWH1) were similar to the general population. However, transgender women living with HIV-1 faced a significantly higher risk of severe COVID-19 outcomes.

Area of Science:

  • Infectious Diseases
  • Public Health
  • HIV Medicine

Background:

  • Understanding COVID-19 severity factors in people living with HIV-1 (PLWH1) is crucial for targeted interventions.
  • Previous research has not fully elucidated specific risk factors for severe COVID-19 within this vulnerable population.

Purpose of the Study:

  • To identify risk factors associated with severe or critical COVID-19 outcomes in a cohort of PLWH1.
  • To compare these risk factors with those observed in the general population.

Main Methods:

  • An observational, retrospective, single-center cohort study was conducted.
  • Included were PLWH1 diagnosed with COVID-19 between February 1 and November 30, 2020.
  • Stepwise forward selection was used to determine risk factors for severe/critical COVID-19.

Main Results:

  • 129 PLWH1 with COVID-19 were analyzed; 98 had confirmed diagnoses.
  • Severe/critical COVID-19 was associated with older age, higher BMI, diabetes, and chronic kidney disease.
  • Transgender women living with HIV-1 demonstrated a significantly higher risk (OR: 4.9).

Conclusions:

  • Key risk factors for severe COVID-19 in PLWH1 mirror those in the general population.
  • Transgender women living with HIV-1 represent a specific subgroup at elevated risk for severe COVID-19.
  • Viral suppression and CD4 counts were not associated with COVID-19 severity in this cohort.
Abstract

Keywords:
COVID-19HIVRisk factors

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