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Loperamide associated necrotising enterocolitis.

C B Chow, S H Li, N K Leung

    Acta Paediatrica Scandinavica
    |November 1, 1986
    PubMed
    Summary
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    Necrotising enterocolitis (NEC) can occur in infants after neonatal period, even without typical risk factors. Loperamide treatment for diarrhea may play a role in NEC development, warranting further investigation.

    Area of Science:

    • Pediatrics
    • Neonatology
    • Gastroenterology

    Background:

    • Necrotising enterocolitis (NEC) is a severe gastrointestinal condition primarily affecting premature infants.
    • While typically a neonatal issue, NEC can manifest later in infancy, presenting diagnostic challenges.

    Observation:

    • Two cases of NEC were observed in infants outside the typical neonatal period.
    • Neither infant presented with common predisposing factors for NEC.
    • Both infants experienced paralytic ileus following loperamide therapy for mild diarrhea preceding NEC onset.

    Findings:

    • The study highlights two cases of necrotising enterocolitis (NEC) in infants beyond the neonatal period.
    • These infants lacked typical NEC risk factors but developed paralytic ileus after loperamide administration for diarrhea.

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  • This suggests a potential association between loperamide use and NEC pathogenesis.

    • Implications:

    • Investigate the potential role of loperamide in the development of necrotising enterocolitis.
    • Consider loperamide's safety profile in infants, especially for non-severe gastrointestinal issues.
    • Further research is needed to understand the mechanisms linking loperamide to NEC in infants.