Dynamic Supramolecular Hydrogels: Regulating Hydrogel Properties through Self-Complementary Quadruple Hydrogen Bonds
Guangzhao Zhang1, Yunhua Chen2, Yonghong Deng3
1Research Institute of Materials Science, South China University of Technology, Guangzhou 510640, China.
ACS Macro Letters
|June 2, 2022
Summary
This study introduces a novel supramolecular hydrogel formed from a triblock copolymer. This dynamic material exhibits self-healing and injectability, showing high viability for encapsulated mesenchymal stem cells.
Area of Science:
- Materials Science
- Polymer Chemistry
- Biomedical Engineering
Background:
- Supramolecular hydrogels offer dynamic properties for advanced applications.
- Designing responsive materials requires precise control over polymer architecture and stimuli-responsiveness.
Purpose of the Study:
- To develop a novel supramolecular hydrogel with desirable dynamic properties.
- To investigate the hydrogelation mechanism and its potential in cell therapy.
Main Methods:
- Synthesis of an ABA triblock copolymer with poly(ethylene oxide) and poly(N-isopropylacrylamide) blocks incorporating ureido pyrimidinone moieties.
- Characterization of hydrogelation triggered by temperature-induced phase transition (LCST) and self-assembly.
- Evaluation of dynamic properties including shear-thinning, self-healing, and thermo-reversibility.
- Assessment of cell viability (mesenchymal stem cells) post-encapsulation and injection.
Main Results:
- Rapid hydrogelation above the LCST of the copolymer.
- Demonstration of shear-thinning, self-healing, thermo-reversible, and injectable properties.
- High viability (>90%) of mesenchymal stem cells after encapsulation and injection.
- Successful 3D construction of complex objects using the hydrogel.
Conclusions:
- The developed supramolecular hydrogel possesses a unique combination of dynamic physical properties.
- The material shows significant promise for supporting cell and drug therapies due to its biocompatibility and injectability.
- The UPy-functionalized triblock copolymer provides a versatile platform for creating advanced biomaterials.
