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Desensitization Protocol to Carboplatin: A Technical Report.

Cornelia Nitipir1,2, Andreea Parosanu1,2, Ana Maria Popa2,1

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Summary

Hypersensitivity reactions to carboplatin chemotherapy can be managed effectively. A desensitization protocol allows patients to continue treatment and benefit from its antitumor effects, avoiding permanent discontinuation.

Keywords:
carboplatindesensitizationhypersensitivityprotocolreaction

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Area of Science:

  • Oncology
  • Clinical Pharmacy
  • Internal Medicine

Background:

  • Carboplatin is a cornerstone chemotherapy agent for various solid tumors.
  • Hypersensitivity reactions (HSRs) are a frequent and significant side effect of carboplatin, increasing with cumulative dose.
  • HSRs can necessitate treatment cessation, limiting therapeutic benefit.

Purpose of the Study:

  • To detail a carboplatin desensitization protocol.
  • To enable continued carboplatin therapy in patients experiencing hypersensitivity reactions.
  • To maintain the antitumor efficacy of carboplatin by preventing treatment discontinuation.

Main Methods:

  • Implementation of a specific desensitization protocol for carboplatin administration.
  • Monitoring patients for hypersensitivity reactions during the desensitization process.
  • Continuation of carboplatin chemotherapy following successful desensitization.

Main Results:

  • The described desensitization protocol effectively manages carboplatin-induced hypersensitivity reactions.
  • Patients can continue receiving carboplatin chemotherapy without permanent discontinuation.
  • The protocol facilitates sustained antitumor effects of carboplatin.

Conclusions:

  • Carboplatin desensitization is a viable strategy to manage HSRs.
  • This approach allows for the continued use of carboplatin, preserving its oncological benefits.
  • The protocol developed at the University Emergency Hospital, Bucharest, provides a model for managing carboplatin hypersensitivity.