Related Experiment Video

Updated: Sep 21, 2025

Assessment of Oxidative Damage in the Primary Mouse Ocular Surface Cells/Stem Cells in Response to Ultraviolet-C UV-C Damage
12:59

Assessment of Oxidative Damage in the Primary Mouse Ocular Surface Cells/Stem Cells in Response to Ultraviolet-C UV-C Damage

Published on: February 15, 2020

6.3K

Oxidative stress and visual system: a review

Samanta Taurone1, Massimo Ralli2, Marco Artico2

  • 1IRCCS - Fondazione Bietti, Rome, Italy.

EXCLI Journal
|June 2, 2022
PubMed

Insights

Alpha-lipoic acid (ALA) and superoxide dismutase (SOD) show potential in protecting the visual system from oxidative stress and neurodegeneration. Combining ALA and SOD may prevent age-related ocular damage and reduce cell death.

Area of Science:

  • Ophthalmology
  • Neuroscience
  • Biochemistry

Background:

  • Oxidative stress significantly impacts tissues, with the visual system being particularly vulnerable due to light exposure.
  • Growing scientific interest exists in antioxidant and anti-inflammatory compounds for treating visual system conditions.

Purpose of the Study:

  • To review the literature on antioxidant molecules for visual system conditions.
  • To focus on alpha-lipoic acid (ALA) and superoxide dismutase (SOD) in mitigating neurodegeneration in the ocular segment.

Main Methods:

  • Literature review focusing on antioxidant agents.
  • Analysis of studies investigating ALA and SOD's effects on ocular neurodegeneration and oxidative stress.

Main Results:

  • ALA and SOD demonstrate protective effects against neurodegeneration in the optic nerve and retina.
  • Co-administration of ALA and SOD effectively lowers oxidative stress levels.
  • Combined treatment prevents neurodegeneration and reduces apoptotic processes in the ocular segment.

Conclusions:

  • ALA and SOD are promising antioxidants for protecting the aging visual system.
  • Combined ALA and SOD therapy offers a potential strategy to combat oxidative stress-induced ocular neurodegeneration.
Keywords:
alpha-lipoic acid (ALA)antioxidantsretina and optic nerve agingsuperoxide dismutase (SOD)

More Related Videos

Quantification of Reactive Oxygen Species Using 2′,7′-Dichlorofluorescein Diacetate Probe and Flow-Cytometry in Müller Glial Cells14:25

Quantification of Reactive Oxygen Species Using 2′,7′-Dichlorofluorescein Diacetate Probe and Flow-Cytometry in Müller Glial Cells

Published on: May 13, 2022

7.0K
Induction and Analysis of Oxidative Stress in Sleeping Beauty Transposon-Transfected Human Retinal Pigment Epithelial Cells10:00

Induction and Analysis of Oxidative Stress in Sleeping Beauty Transposon-Transfected Human Retinal Pigment Epithelial Cells

Published on: December 11, 2020

2.7K

Related Concept Videos

Photoreceptors and Visual Pathways01:22

Photoreceptors and Visual Pathways

At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category,...
6.5K
Visual System01:26

Visual System

Light enters the eye through the cornea, a transparent, dome-shaped surface covering the surface of the eyeball that helps to direct and focus incoming light. This light is then channeled toward the pupil, an adjustable opening whose size is controlled by the iris. The iris, a pigmented muscle, regulates the amount of light entering the eye by contracting or dilating the pupil, thereby ensuring optimal light levels for clear vision.
Once through the pupil, the light passes through the lens, a...
708
Color Vision01:24

Color Vision

Color perception begins in the retina, the light-sensitive layer at the back of the eye. Two main theories explain how colors are seen: the trichromatic theory and the opponent-process theory. The trichromatic theory, proposed by Thomas Young in 1802 and extended by Hermann von Helmholtz in 1852, suggests that color vision is based on three types of cone receptors in the retina. These cones are sensitive to different but overlapping ranges of wavelengths corresponding to red, blue, and green.
741