Related Experiment Video

Updated: Sep 21, 2025

Ultrasound-Guided Orthotopic Implantation of Murine Pancreatic Ductal Adenocarcinoma
06:21

Ultrasound-Guided Orthotopic Implantation of Murine Pancreatic Ductal Adenocarcinoma

Published on: November 19, 2019

11.5K

The Role of Feedback Loops in Targeted Therapy for Pancreatic Cancer

Weigang Gu1, HongZhang Shen1, Lu Xie1

  • 1Department of Gastroenterology, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Frontiers in Oncology
|June 2, 2022
PubMed

Insights

Feedback loops significantly influence pancreatic cancer progression and treatment response. Modulating these feedback loops offers a promising strategy for developing targeted therapies for pancreatic cancer.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Signaling

Background:

  • Pancreatic cancer is a leading cause of cancer mortality globally.
  • Limited treatment options and poor survival rates highlight the need for novel therapeutic strategies.
  • Complex signaling networks in pancreatic cancer hinder precise targeted drug development.

Purpose of the Study:

  • To review the role of feedback loops in pancreatic cancer progression.
  • To summarize the interplay between feedback loops and signaling pathways in pancreatic cancer.
  • To highlight advances in targeting feedback loops for pancreatic cancer treatment.

Main Methods:

  • Literature review of research on feedback loops in pancreatic cancer.
  • Analysis of the connection between feedback loops and key signaling pathways.
  • Summary of recent therapeutic interventions targeting feedback loops.

Main Results:

  • Feedback loop regulation is implicated in pancreatic cancer development and therapeutic response.
  • Specific feedback loops are associated with critical signaling pathways driving pancreatic cancer.
  • Interventions targeting feedback loops show potential in preclinical and clinical studies.

Conclusions:

  • Feedback loops are crucial in pancreatic cancer pathogenesis and drug resistance.
  • Targeting feedback loops represents a viable strategy for novel pancreatic cancer therapies.
  • Modulation of feedback loops could enhance the efficacy of targeted treatments for pancreatic cancer.
Keywords:
feedback loopsnegative regulationpancreatic cancerpositive regulationtargeted therapy

More Related Videos

Flow Cytometry-Based Isolation and Therapeutic Evaluation of Tumor-Infiltrating Lymphocytes in a Mouse Model of Pancreatic Cancer07:55

Flow Cytometry-Based Isolation and Therapeutic Evaluation of Tumor-Infiltrating Lymphocytes in a Mouse Model of Pancreatic Cancer

Published on: January 17, 2025

1.1K
Author Spotlight: Reprogramming Cancer Cells to iPSCs to Study Disease Progression and Treatment Targets07:08

Author Spotlight: Reprogramming Cancer Cells to iPSCs to Study Disease Progression and Treatment Targets

Published on: February 2, 2024

928

Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
7.8K
Cell Signaling Feedback Loops01:07

Cell Signaling Feedback Loops

Positive and negative feedback loops are crucial for regulating biological signaling systems. These feedback loops are processes that connect output signals to their inputs.
Negative feedback loops
Most signaling systems have negative feedback loops that can perform different functions such as output limiter, and adaptation.
Output limiter
Upon receiving an input signal, the cellular response rapidly increases until a threshold is reached. Beyond this threshold, a negative feedback loop...
6.6K
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
5.1K
Feedback Loops01:01

Feedback Loops

In most cases, excessive hormone production is prevented by negative feedback—a loop that starts with a stimulus inducing the release of a particular substance, like a hormone, to maintain a certain level before triggering a signal that results in a decrease in further release of the hormone.
58.7K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
3.9K
Positive and Negative Feedback Loops01:18

Positive and Negative Feedback Loops

Animal organs and organ systems constantly adjust to internal and external changes through a process called homeostasis ("steady state"). Examples of these changes include regulation of the level of glucose or calcium in the blood or internal responses to external temperatures. Homeostasis requires  maintaining an internal dynamic equilibrium:
20.2K