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Non-Coding RNA in Penile Cancer
Jaqueline Diniz Pinho1,2,3, Gyl Eanes Barros Silva2, Antonio Augusto Lima Teixeira-Júnior2,4
1Zé Doca Center for Higher Studies, State University of Maranhão, Zé Doca, Brazil.
Frontiers in Oncology
|June 2, 2022
Summary
Non-coding RNAs (ncRNAs) show promise as biomarkers for penile cancer (PC). This review explores their role in penile carcinogenesis and clinical relevance for diagnosis and treatment.
Area of Science:
- Oncology
- Molecular Biology
- Biochemistry
Background:
- Penile cancer (PC) remains a significant health concern, particularly in developing nations like Brazil.
- Effective patient management, especially regarding lymphadenectomy, requires better molecular markers.
- Non-coding RNAs (ncRNAs), including microRNAs, piRNAs, and LncRNAs, are emerging as potential biomarkers in various cancers.
Purpose of the Study:
- To consolidate current knowledge on ncRNAs implicated in penile cancer.
- To enhance understanding of the penile carcinogenesis process.
- To evaluate the clinical relevance of ncRNAs in PC management.
Main Methods:
- Literature review of studies investigating ncRNAs in penile cancer.
- Analysis of the role of microRNAs, piRNAs, and LncRNAs in PC development.
- Assessment of the diagnostic and prognostic potential of ncRNAs.
Main Results:
- ncRNAs are increasingly recognized for their involvement in penile carcinogenesis.
- Specific ncRNAs demonstrate potential as diagnostic and prognostic biomarkers for PC.
- The use of ncRNAs in paraffin-embedded samples facilitates retrospective studies.
Conclusions:
- ncRNAs represent a novel class of biomarkers for penile cancer.
- These molecules hold significant potential for improving PC diagnosis, prognosis, and treatment selection.
- Further research into ncRNAs can advance PC management strategies.
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