Related Experiment Video

Updated: Sep 21, 2025

A Magnetic Resonance Imaging-based Computational Protocol for Analysis of Plaque Morphology and Hemodynamics in Patients with Carotid Artery Stenosis
09:36

A Magnetic Resonance Imaging-based Computational Protocol for Analysis of Plaque Morphology and Hemodynamics in Patients with Carotid Artery Stenosis

Published on: August 12, 2025

113

Carotid Siphon Calcification Predicts the Symptomatic Progression in Branch Artery Disease With Intracranial Artery

Duanlu Hou1, Xiaoli Yang1, Yuanyuan Wang1

  • 1Department of Neurology, Shanghai Fifth People's Hospital (D.H., X.Y., Y.W., S.H., D.W.), Fudan University, Shanghai, China.

Arteriosclerosis, Thrombosis, and Vascular Biology
|June 2, 2022
PubMed

Insights

Carotid siphon calcification is linked to branch atheromatous disease (BAD) progression in intracranial atherosclerosis. CT values of this calcification can predict symptomatic progression, highlighting its importance in B-type disease.

Area of Science:

  • Neurology
  • Cardiovascular Medicine
  • Radiology

Background:

  • Arterial calcification in the aortic arch, carotid bifurcation, or siphon is associated with cardiovascular disease.
  • The link between arterial calcification and branch atheromatous disease (BAD) progression in intracranial atherosclerosis remains understudied.

Purpose of the Study:

  • To investigate the prevalence of arterial calcification in patients with BAD progression.
  • To determine if arterial calcification predicts symptomatic progression in intracranial arterial atherosclerotic disease.

Main Methods:

  • A cohort of 310 ischemic stroke patients was analyzed, divided into BAD (110) and non-BAD (200) groups.
  • Baseline characteristics, lipids, and arterial calcification were assessed using computed tomography and angiography.
  • Logistic regression, ROC curves, and linear regression analyzed associations between calcification, lipids, and BAD progression.

Main Results:

  • Carotid siphon calcification was more prevalent in patients with BAD (P=0.01) and intracranial artery stenosis (P<0.001).
  • Computed tomography values of carotid siphon calcification independently predicted symptomatic progression (P=0.01).
  • A significant linear correlation was found between oxidized lipids and calcification density in BAD patients (beta=-0.73, P=0.0048).

Conclusions:

  • Carotid siphon calcification is associated with BAD and predicts symptomatic progression in intracranial arterial atherosclerotic disease.
  • Carotid calcification plays a crucial role in B-type intracranial arterial atherosclerotic disease.
Abstract

Keywords:
angiographyatherosclerosiscarotid arterylow-density lipoproteinstroke

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