Related Experiment Video
Updated: Sep 21, 2025
06:47
Microfluidics in Assessing Platelet Function
Published on: November 8, 2024
1.1K
SYMPHONY consortium: Orchestrating personalized treatment for patients with bleeding disorders
Marjon H Cnossen1, Iris van Moort2, Simone H Reitsma1
1Department of Pediatric Hematology and Oncology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Journal of Thrombosis and Haemostasis : JTH
|June 2, 2022
Summary
The SYMPHONY consortium aims to personalize treatment for inborn bleeding disorders by studying variations in bleeding. This research will improve diagnosis and treatment strategies for patients.
Area of Science:
- Hematology
- Genetics
- Personalized Medicine
Background:
- Increasing treatment options and costs for inborn bleeding disorders present challenges.
- An integrated, interdisciplinary national research program has been established to address these issues.
Purpose of the Study:
- To orchestrate personalized treatment for patients with inborn bleeding disorders.
- To unravel mechanisms behind inter-individual variations in bleeding phenotype.
Main Methods:
- Investigating both diagnosed and undiagnosed patients with inborn bleeding disorders.
- Research categorized under diagnosis, treatment, and fundamental research themes.
- Collaborations between patients and researchers from diverse expertise areas.
Main Results:
- Research questions encompass diagnosis, treatment, and fundamental research.
- Work packages address specific domains within these themes.
- Collaborations foster intellectual property and enhance research impact.
Conclusions:
- SYMPHONY will research all aspects of care and treatment individualization for inborn bleeding disorders.
- Focus on diagnostic innovations, molecular genetics, and cellular models of hemostasis.
- Expected health care innovations with long-term clinical and societal impact.
Related Concept Videos
01:24Disorders of Hemostasis
1.2K
Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
1.2K
02:50Combination Therapies and Personalized Medicine
5.1K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
5.1K
01:29Venous Thrombosis III: Interprofessional Care
32
Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
32
01:30Venous Thrombosis IV: Nursing Management
31
Nursing management begins with a thorough assessment of the patient's health history. Key factors include trauma to veins, peripherally inserted central catheters, varicose veins, recent pregnancy or childbirth, surgery, bacteremia, prolonged bed rest, atrial fibrillation, COPD, heart failure, cancer, coagulation disorders, myocardial infarction, spinal cord injury, stroke, prolonged travel, recent bone fractures, and dehydration. Review medication intake, particularly oral contraceptives,...
31
01:30Anticoagulant Drugs: Low-Molecular-Weight Heparins
938
Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
938
01:27Peripheral Artery Disease III: Interprofessional Care
38
Peripheral Artery Disease (PAD) is characterized by narrowed arteries that diminish blood flow to the extremities. Effective management of PAD requires an interprofessional approach involving various healthcare professionals. The critical aspects of interprofessional care for PAD patients focus on risk factor modification, drug therapy, exercise therapy, nutrition therapy, critical limb ischemia care, and interventional radiology and surgical procedures.The primary treatment goal for PAD...
38