Related Experiment Video

Updated: Sep 21, 2025

Noninvasive Assessment of Cardiac Abnormalities in Experimental Autoimmune Myocarditis by Magnetic Resonance Microscopy Imaging in the Mouse
12:24

Noninvasive Assessment of Cardiac Abnormalities in Experimental Autoimmune Myocarditis by Magnetic Resonance Microscopy Imaging in the Mouse

Published on: June 20, 2014

10.0K

Myocarditis after COVID-19 mRNA vaccination: A systematic review of case reports and case series

Dae Yong Park1, Seokyung An2, Amandeep Kaur3

  • 1Department of Medicine, John H. Stroger Jr Hospital of Cook County, Chicago, Illinois, USA.

Clinical Cardiology
|June 2, 2022
PubMed

Insights

COVID-19 vaccine-associated myocarditis typically affects younger males, presenting with chest pain days after the second dose. While rare, myocarditis cases generally have a favorable prognosis, underscoring the importance of continued vaccination efforts.

Area of Science:

  • Cardiology
  • Immunology
  • Public Health

Background:

  • COVID-19 pandemic necessitated rapid vaccine development.
  • Vaccines significantly reduced disease incidence, prevalence, and severity.
  • Rare instances of myocarditis post-vaccination have been documented.

Observation:

  • A systematic review identified 275 cases of vaccine-associated myocarditis.
  • The condition predominantly affected younger males (14:1 ratio), with a mean age of 26.7 years.
  • Myocarditis commonly occurred after the second vaccine dose (86.9%) with a median onset of 3.7 days.

Findings:

  • Common symptoms included chest pain (95.2%), elevated troponin (100%), and ECG ST elevation (68.5%).
  • Treatment involved NSAIDs (81.4%) and colchicine (33.1%).
  • The prognosis was generally favorable, with a reported mortality of 1.1%.

Implications:

  • COVID-19 vaccine-associated myocarditis has distinct clinical features, primarily in young males.
  • Diagnosis relies on excluding other causes of myocarditis.
  • Physicians should encourage vaccination while monitoring for rare adverse events like myocarditis.
Abstract

Keywords:
COVIDCOVID-19myocarditisvaccinationvaccine

More Related Videos

Delivery of Modified mRNA in a Myocardial Infarction Mouse Model06:03

Delivery of Modified mRNA in a Myocardial Infarction Mouse Model

Published on: June 11, 2020

9.3K
Flow Cytometry-Based Quantification and Analysis of Myocardial B-Cells12:46

Flow Cytometry-Based Quantification and Analysis of Myocardial B-Cells

Published on: August 17, 2022

2.7K

Related Concept Videos

Myocarditis III: Medical Management01:14

Myocarditis III: Medical Management

Myocarditis: Comprehensive Medical ManagementMyocarditis, the heart muscle inflammation, requires a comprehensive medical management strategy that addresses the underlying cause, provides supportive care, manages symptoms, and reduces cardiac workload.Infections and Autoimmune CausesAdminister appropriate antimicrobial therapy when an infectious agent causes myocarditis. For instance, penicillin treats infections caused by Group A Streptococcus. In cases where autoimmune processes are...
24
Myocarditis II: Clinical Features and Diagnostic Tests01:27

Myocarditis II: Clinical Features and Diagnostic Tests

Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
34
Myocarditis I: Introduction01:21

Myocarditis I: Introduction

Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
42
Myocarditis IV: Nursing Management01:22

Myocarditis IV: Nursing Management

Myocarditis is an inflammatory condition of the myocardium requiring meticulous nursing management for optimal patient outcomes. Effective management begins with a thorough assessment of the patient's medical history, paying close attention to past infections, autoimmune disorders, travel history, and exposure to toxins or drugs. Recent viral infections and systemic diseases are particularly relevant due to their potential role in triggering myocarditis.Physical Examination and MonitoringThe...
45
Pericarditis I: Introduction01:22

Pericarditis I: Introduction

Pericarditis is defined as the inflammation of the pericardium, the thin, sac-like membrane surrounding the heart. This condition can cause significant chest pain and other symptoms, often necessitating medical intervention. The pericardium has two layers: the inner visceral layer and the outer parietal layer, separated by a small amount of fluid that reduces friction during heartbeats.Types of PericarditisPericarditis can be classified into several types based on the duration and nature of the...
27
Pericarditis III: Medical Management01:17

Pericarditis III: Medical Management

The primary objectives of managing pericarditis are to determine the underlying cause, provide effective therapy for treatment and symptom relief, and promptly detect signs and symptoms of cardiac tamponade. The following outlines the essential aspects of medical management for pericarditis:ObjectivesDetermine the Cause: Identifying the underlying cause of pericarditis is crucial for targeted treatment. Causes include viral infections, autoimmune diseases, post-cardiac injury syndrome, and...
33