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Updated: Sep 21, 2025

Improving IV Insulin Administration in a Community Hospital
Published on: June 11, 2012
Hypoglycaemia incidence with a simple, low-dose insulin protocol for adult diabetic ketoacidosis
Niti Patel1, Michael Cusumano1, Jessica Lorenson1
1Department of Pharmacy, HSHS St. John's Hospital, Springfield, IL, USA.
Objective:
The objective of this study is to validate the glycaemic safety of a simple insulin protocol using weight-based insulin rates adapted from American guidance for the management of adult diabetic ketoacidosis.
Methods:
Measures of hypoglycaemia were retrospectively assessed in a single cohort of inpatient adults. The primary outcome was incidence of hypoglycaemia during insulin infusion.
Key Findings:
Hypoglycaemia during infusion occurred in 6/81 patients (7% [95% CI 3-16%]). Five of these occurrences were associated with protocol nonadherence.
Conclusions:
The glycaemic safety of a novel, variable-rate insulin protocol directly incorporating weight-based infusion rates is supported by this single-centre study.
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