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Disorders of the Male Reproductive System

Disorders of the Male Reproductive System

Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....

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Updated: Sep 21, 2025

A Murine Orthotopic Bladder Tumor Model and Tumor Detection System

A Murine Orthotopic Bladder Tumor Model and Tumor Detection System

Published on: January 12, 2017

PSA density is associated with BPH cellular composition.

Liwei Jia¹, Douglas W Strand², Ramy S Goueli²

¹Department of Pathology, UT Southwestern Medical Center, Dallas, Texas, USA.

|June 2, 2022

Summary

This summary is machine-generated.

Prostate-specific antigen density may help estimate benign prostatic hyperplasia cellular content, potentially improving treatment selection for 5-alpha reductase inhibitors. Further research is needed to confirm responsiveness based on glandular content.

Keywords:

PSA density benign prostatic hyperplasia histology prostate specific antigen prostate volume

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Isolation, Culture, and Characterization of Prostate Cancer-Associated Fibroblasts

Isolation, Culture, and Characterization of Prostate Cancer-Associated Fibroblasts

Published on: August 1, 2025

Area of Science:

Urology
Pathology
Biochemistry

Background:

Current guidelines recommend 5-alpha reductase inhibitors (5ARI) for benign prostatic hyperplasia (BPH) with specific prostate volume and PSA levels.
Benign prostatic hyperplasia exhibits significant variability, leading to inconsistent patient responses to 5ARI treatment.
Noninvasive assessment of prostate cellular composition could enhance clinical decision-making for BPH management.

Purpose of the Study:

To investigate the association between prostate histological composition and noninvasive biomarkers.
To determine if PSA density can predict the glandular content of BPH specimens.
To explore the potential of PSA density in optimizing patient selection for 5ARI therapy.

Main Methods:

Histological analysis of 307 BPH specimens to score stromal-glandular content.
Correlation of histological findings with clinical variables including total PSA, prostate volume, and PSA density.
Application of univariate and multivariate linear regression for statistical analysis.

Main Results:

Glandular composition in 5ARI-naïve men was positively associated with PSA and PSA density.
Statistical modeling indicated that a PSA density of ≤0.05 ng/mL² corresponded to ≤30% glandular composition with 76% sensitivity.
This suggests PSA density is a significant predictor of BPH cellular makeup.

Conclusions:

PSA density shows promise as a key variable for estimating BPH cellular composition.
Improved patient selection for 5ARI treatment may be achievable using PSA density.
Further investigation is required to confirm if higher glandular content correlates with enhanced 5ARI treatment response.