New Approaches toward Building Csp -P bond: A Two-Decade Overview
Lucas Mele1, Jean Luc Pirat1, Tahar Ayad1
1ICGM Univ Montpellier, CNRS, ENSCM, Montpellier, France.
Chemistry (Weinheim an Der Bergstrasse, Germany)
|June 2, 2022
Summary
Recent advances have expanded the synthesis of alkynylphosphorus compounds, offering greener methods using catalysis or metal-free couplings. This review covers key developments since 2000.
Area of Science:
- Organic Chemistry
- Organophosphorus Chemistry
Background:
- The synthesis of alkynylphosphorus compounds has significantly advanced in the last 20 years.
- The original synthetic toolbox for these compounds was limited.
Purpose of the Study:
- To provide a comprehensive review of recent methodologies for synthesizing alkynylphosphorus compounds.
- To highlight greener synthetic approaches and mechanistic insights.
Main Methods:
- Exploration of sustainable catalysis and direct metal-free couplings.
- Focus on copper, palladium, nickel, and silver catalytic systems.
- Inclusion of photocatalytic reactions.
Main Results:
- Significant expansion of synthetic methods for alkynylphosphorus compounds.
- Detailed mechanistic insights for various catalytic systems.
- Coverage of publications from 2000 to March 2022.
Conclusions:
- Modern synthetic strategies offer improved and potentially greener routes to alkynylphosphorus compounds.
- Catalysis and metal-free approaches are key to advancing this field.
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