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Updated: Sep 21, 2025

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An In Vitro Model for Studying Cellular Transformation by Kaposi Sarcoma Herpesvirus
Published on: August 25, 2017
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Kaposi's sarcoma management from a plastic surgery perspective
Selman Taskin1, Tugce Yasak1, S Tiber Mentese1
1Prof. Dr. Cemil Tascioglu City Hospital, Plastic Reconstructive and Aesthetic Surgery Clinic, Istanbul, Turkey.
The Journal of Dermatological Treatment
|June 2, 2022
Summary
Surgical excision is an effective treatment for Kaposi's sarcoma (KS), a tumor linked to Human Herpes Virus 8. This one-stage approach offers advantages over other therapies for managing KS lesions.
Area of Science:
- Oncology
- Dermatology
- Plastic Surgery
Background:
- Kaposi's sarcoma (KS) is a low-grade angioproliferative tumor associated with Human Herpes Virus 8.
- The plastic surgery literature on KS management is limited despite patient referrals for surgical excision.
Purpose of the Study:
- To highlight differences in Kaposi's sarcoma management.
- To underscore the importance of a multidisciplinary approach in selecting optimal treatment for KS lesions.
Main Methods:
- Retrospective analysis of 30 patients diagnosed with KS between March 2015 and January 2020.
- Surgical excision with margins of 0.5-1 cm over deep skin fascia for lesions up to 2*3 cm.
- Preoperative HIV testing and comprehensive whole-body examinations were conducted.
Main Results:
- Primary repair was utilized for 40 lesions in 23 patients.
- Skin grafts were used for 12 lesions in 8 patients.
- Local skin flaps and a pedicled regional flap were employed in four and one patient, respectively.
Conclusions:
- One-stage surgical excision of Kaposi's sarcoma lesions offers significant advantages.
- This approach is more efficient than therapies like radiotherapy, laser, or chemotherapy, which require multiple sessions.
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