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Prior beetroot juice ingestion offsets endothelial dysfunction following prolonged sitting.

Takuma Morishima1, Motoyuki Iemitsu2, Shumpei Fujie2

  • 1Faculty of Liberal Arts and Sciences, Chukyo University, Aichi, Japan.

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Beetroot juice supplementation before prolonged sitting prevents leg endothelial dysfunction. This dietary nitrate strategy enhances nitric oxide (NO) bioavailability, mitigating negative vascular effects from inactivity.

Keywords:
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Area of Science:

  • Cardiovascular Physiology
  • Nutritional Science
  • Sports Medicine

Background:

  • Prolonged sitting causes endothelial dysfunction, a risk factor for cardiovascular disease.
  • Nutritional interventions to counteract sedentary behavior's vascular effects are needed.
  • Beetroot juice (BRJ) is rich in nitrates, which increase nitric oxide (NO) bioavailability.

Purpose of the Study:

  • To investigate if BRJ ingestion can prevent endothelial dysfunction in the leg induced by prolonged sitting.
  • To assess the impact of BRJ on nitric oxide bioavailability and vascular function after sedentary periods.

Main Methods:

  • Healthy participants (males and females) underwent two trials: placebo (PL) and BRJ ingestion before 3 hours of sitting.
  • Measurements included popliteal artery flow-mediated dilation (FMD), blood pressure, and plasma nitrate/NOx concentrations.
  • Popliteal artery diameter and blood velocity were monitored hourly during sitting.

Main Results:

  • Sitting reduced popliteal artery blood flow and shear rate similarly in both trials.
  • BRJ ingestion significantly increased plasma nitrate and NOx concentrations.
  • Endothelial function (FMD) was impaired after sitting in the PL trial but preserved in the BRJ trial.

Conclusions:

  • Prior ingestion of BRJ effectively prevents endothelial dysfunction in the leg caused by prolonged sitting.
  • Dietary nitrate supplementation through BRJ enhances NO bioavailability, offering a protective vascular effect against sedentary behavior.
  • This study highlights BRJ as a potential nutritional strategy to mitigate the adverse vascular consequences of prolonged sitting.