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Marie Beaud, Bernard Lardy, Jean-Luc Bosson

    Geriatrie Et Psychologie Neuropsychiatrie Du Vieillissement
    |June 2, 2022
    PubMed
    Summary
    This summary is machine-generated.

    A formula to correct albumin levels during prolonged inflammation is not suitable for acute inflammation in elderly patients. Measured albumin levels, considered stable in acute inflammation, can be used for biological nutritional assessment.

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    Area of Science:

    • Geriatrics
    • Biochemistry
    • Clinical Nutrition

    Background:

    • Accurate albumin interpretation is vital for elderly biological nutritional assessment (BNA).
    • Inflammation significantly alters albumin levels, complicating BNA.
    • A formula exists to correct albumin for prolonged inflammation.

    Purpose of the Study:

    • To evaluate if a correction formula for prolonged inflammation can be extrapolated to acute inflammation.
    • To assess the stability of measured albumin levels during acute inflammation.
    • To determine the utility of measured albumin for BNA in acute inflammatory states.

    Main Methods:

    • Prospective, single-center observational study of hospitalized elderly patients.
    • Clinical and biological data collected on days 1 and 8.

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  • Comparison of day 1 corrected albumin with day 8 measured albumin.

    • Main Results:

    • The correlation between day 1 corrected albumin and day 8 measured albumin was weak (ρ = 0.58).
    • A significant mean difference of 2.9 mg/L was observed between corrected and measured albumin.
    • Measured albumin levels showed a strong correlation (ρ = 0.74) between day 1 and day 8, with minimal mean difference (0.4 mg/L).

    Conclusions:

    • The proposed albumin correction formula is not applicable to acute inflammatory situations.
    • Measured albuminemia appears stable during acute inflammation.
    • Measured albuminemia, within a clinical context, can serve as a reliable reference for BNA.