Related Experiment Video

Updated: Sep 21, 2025

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
10:03

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty

Published on: January 28, 2020

5.4K

Can C-reactive protein-based biomarkers be used as predictive of 30-day mortality in elderly hip fractures?A

Orhan Balta1, Harun Altınayak2, Mehtap Gürler Balta3

  • 1Department of Orthopaedics and Traumatology, Gaziosmanpaşa University Faculty of Medicine Hospital, Tokat-Turkey.

Ulusal Travma Ve Acil Cerrahi Dergisi = Turkish Journal of Trauma & Emergency Surgery : TJTES
|June 2, 2022
PubMed

Insights

The pre-operative C-reactive protein-to-albumin (CRP/ALB) ratio can predict 30-day mortality in hip fracture patients. This simple blood test is recommended for routine pre-operative assessment in elderly patients.

Area of Science:

  • Geriatric Medicine
  • Orthopedic Surgery
  • Biomarkers

Background:

  • C-reactive protein-to-lymphocyte ratio (CLR), C-reactive protein/albumin (CRP/ALB), and CRP are established prognostic factors in oncology and digestive surgery.
  • The predictive value of CLR for mortality in hip fracture patients remains uninvestigated.
  • This study aimed to assess the association between pre-operative CLR, CRP/ALB, and CRP levels and patient survival following hip fracture.

Purpose of the Study:

  • To investigate the association between pre-operative C-reactive protein-to-lymphocyte ratio (CLR), C-reactive protein/albumin (CRP/ALB) ratio, and C-reactive protein (CRP) levels with patient survival after hip fracture surgery.
  • To determine if these inflammatory markers can predict short-term mortality in hip fracture patients.
  • To evaluate the utility of CLR, CRP/ALB, and CRP as prognostic indicators in this specific patient population.

Main Methods:

  • Retrospective review of medical records for hip fracture patients undergoing surgery between January 2016 and December 2019.
  • Patients were categorized into two groups: mortality within 1 month (Group E) and mortality after 1 month or survival (Group S).
  • Evaluated 19 preoperative and postoperative parameters, including various blood markers (hemoglobin, CRP, albumin, lymphocytes, neutrophils, monocytes, platelets), inflammatory ratios (PLR, NLR, LMR, CLR, CRP/ALB), and clinical factors (age, comorbidities, delirium, infections).

Main Results:

  • A total of 165 elderly patients (mean age 83.09 years) were analyzed.
  • Preoperative CRP, neutrophil count, CLR, and CRP/ALB ratios were significantly higher in the 1-month mortality group (Group E) compared to the survival group (Group S).
  • Univariate analysis identified age, Hb, CRP, and CRP/ALB as significant predictors of 1-month mortality. ROC analysis indicated CRP/ALB ratio had the highest AUC, sensitivity, and specificity (cutoff 12.42).

Conclusions:

  • The pre-operative CRP/ALB ratio is a significant predictor of 30-day mortality in elderly patients with intertrochanteric femur fractures.
  • Routine pre-operative measurement of CRP and albumin is recommended for anesthesia preparation in these patients.
  • The CRP/ALB ratio offers a valuable, easily accessible biomarker for risk stratification in hip fracture patients.
Abstract

More Related Videos

Cutoff Value of Phase Angle by Bioelectrical Impedance Analysis at Admission as a Prognostic Factor in Patients with Acute Heart Failure05:16

Cutoff Value of Phase Angle by Bioelectrical Impedance Analysis at Admission as a Prognostic Factor in Patients with Acute Heart Failure

Published on: June 10, 2025

230
Predicting Amputation using Local Circulating Mononuclear Progenitor Cells in Angioplasty-treated Patients with Critical Limb Ischemia07:25

Predicting Amputation using Local Circulating Mononuclear Progenitor Cells in Angioplasty-treated Patients with Critical Limb Ischemia

Published on: September 22, 2020

3.5K

Related Concept Videos

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
230
Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
357
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
27