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The number of androgen receptor CAG repeats and mortality in men

Adrian Heald1,2, Michael Cook3, Leen Antonio4,5

  • 1Department of Endocrinology and Diabetes, Salford Royal Hospital, Salford, UK.

The Aging Male : the Official Journal of the International Society for the Study of the Aging Male
|June 2, 2022
PubMed

Insights

The number of CAG repeats in the androgen receptor (AR) gene may influence mortality risk in men. Both lower and higher repeat numbers showed a trend towards increased mortality in this study.

Area of Science:

  • Genetics and Molecular Biology
  • Aging and Gerontology
  • Public Health and Epidemiology

Background:

  • The androgen receptor (AR) plays a key role in mediating testosterone's effects.
  • CAG repeat length in the AR gene exon-1 is inversely correlated with AR transcriptional activity.
  • Understanding factors influencing male mortality is crucial for public health.

Purpose of the Study:

  • To investigate the association between the number of CAG repeats in the androgen receptor gene and mortality risk in men.
  • To determine if CAG repeat length is an independent predictor of mortality.

Main Methods:

  • A cohort of 312 men aged 40-79 years was recruited from primary care in the UK (European Male Aging Study).
  • Cox proportional hazards modeling was employed to analyze the relationship between CAG repeat number and mortality.
  • Mortality data was collected during a follow-up period.

Main Results:

  • At follow-up, 85 out of 312 men (27%) had died.
  • CAG repeat lengths ranged from 14 to 39, with the most common length being 21 repeats.
  • Men with fewer than 22 CAG repeats (HR 1.46) and more than 23 CAG repeats (HR 1.37) showed a trend towards higher mortality compared to the reference group (22-23 repeats).

Conclusions:

  • The number of CAG repeats in the androgen receptor gene may be a contributing factor to mortality risk in men.
  • Further extensive research is needed to precisely determine the impact of CAG repeat length on male mortality.
Abstract

Keywords:
CAGEMASmalemortalitytestosterone

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