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Related Experiment Video

Updated: Sep 21, 2025

Assessment of Vascular Tone Responsiveness using Isolated Mesenteric Arteries with a Focus on Modulation by Perivascular Adipose Tissues
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PHACTR1 modulates vascular compliance but not endothelial function: a translational study.

Alice Wood1,2, Alexios Antonopoulos3, Surawee Chuaiphichai3,4

  • 1Department of Cardiovascular Sciences, Glenfield Hospital, Leicester, UK.

Cardiovascular Research
|June 2, 2022
PubMed
Summary

The PH domain-containing protein 1 (PHACTR1) gene influences arterial stiffness, particularly in the aorta and carotid artery. This study reveals PHACTR1 plays a key structural role in vascular function.

Keywords:
PHACTR1ArteriesComplianceEndothelial cells

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Area of Science:

  • Cardiovascular Genetics
  • Vascular Biology
  • Molecular Cardiology

Background:

  • The non-coding locus at 6p24, within PHACTR1 intron 3, is a known risk allele for myocardial infarction and vascular diseases.
  • Murine studies suggest Phactr1 involvement in atherosclerosis development, but its role in vascular tone and remodeling remains unclear.

Purpose of the Study:

  • To investigate the function of PHACTR1 in vascular tone and in vivo vascular remodeling.
  • To determine the association between the PHACTR1 rs9349379 locus and vascular function.

Main Methods:

  • Genotyping of the PHACTR1 rs9349379 locus in coronary artery disease (CAD) patients, spontaneous coronary artery dissection (SCAD) patients, and healthy volunteers.
  • Assessment of arterial distensibility in the ascending aorta, descending aorta, and carotid artery.
  • Evaluation of endothelial cell function and ex vivo vascular function in a murine model.

Main Results:

  • A significant association was found between the PHACTR1 locus and arterial distensibility in the ascending aorta and carotid artery.
  • No association was observed in the descending aorta or in SCAD patients.
  • PHACTR1 was not associated with endothelial cell function or ex vivo vascular function in CAD patients or the murine model.

Conclusions:

  • PHACTR1 plays a role in arterial compliance across multiple vascular beds.
  • The findings suggest PHACTR1 has a key structural role within the vasculature.