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Graphene-ophicalcite heterogeneous composite sponge for rapid hemostasis
Bingxin Wu1, Fanglin Du1, Wenjing A1
1State Key Laboratory of Organic-Inorganic Composites, Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology, Beijing 100029, China.
Colloids and Surfaces. B, Biointerfaces
|June 2, 2022
Summary
A novel graphene-ophicalcite composite sponge (GOCS) enhances hemostasis by combining liquid absorption and coagulation stimulation. This advanced hemostatic material significantly reduces clotting time and stops bleeding rapidly.
Area of Science:
- Biomaterials Science
- Materials Chemistry
- Hemostasis Research
Background:
- Effective hemostasis relies on synergistic coagulation stimulation and liquid absorption.
- Current hemostatic materials often lack optimal integration of these properties.
Purpose of the Study:
- To develop a novel heterogeneous composite sponge for enhanced hemostatic efficiency.
- To investigate the synergistic effects of graphene and ophicalcite in a composite hemostatic material.
Main Methods:
- Preparation of a graphene-ophicalcite (OPH) heterogeneous composite sponge (GOCS) using a heterogeneous gradient composite strategy.
- Utilizing cross-linked graphene sponge (CGS) as the skeleton with OPH controllably positioned on the surface.
- Evaluating liquid absorption capacity and coagulation activation properties.
Main Results:
- GOCS demonstrated excellent liquid absorption, concentrating coagulation components at the wound interface.
- OPH on the GOCS surface activated platelets and accelerated coagulation cascade reactions.
- GOCS achieved a significantly lower blood clotting index (33.87%) compared to OPH (46.33%) and CGS (67.53%).
- GOCS stopped bleeding in a rat femoral artery model within 51 seconds.
Conclusions:
- The heterogeneous strategy effectively integrates liquid absorption and coagulation stimulation for superior hemostasis.
- GOCS exhibits significant potential as an advanced hemostatic material.
- This study offers a new approach for designing and preparing efficient hemostatic materials.
