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Immunohistochemistry in Breast Cancer: Practice Points and Pitfalls

Emad A Rakha1, Puay Hoon Tan2

  • 1Department of Histopathology, School of Medicine, The University of Nottingham, and Nottingham University Hospitals NHS Trust, Nottingham, UK.

Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology
|June 2, 2022
PubMed
Abstract

No abstract available in PubMed .

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Immunocytochemistry (ICC) and immunohistochemistry (IHC) are techniques that use antibodies to check for specific proteins or antigens in a sample. The technique was first published by Albert Coons in 1941 to detect the presence of pneumococcal antigen in tissue sections from mice infected with Pneumococcus. Immunocytochemistry helps localization of proteins or antigens in individual cells like blood cells, stem cells, etc., while immunohistochemistry does the same for tissue samples.
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