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Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
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Updated: Sep 21, 2025

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Binder's syndrome: A narrative review.

Hamza Parvez Siddiqui1, Karthik Sennimalai1, Vilas D Samrit1

  • 1Division of Orthodontics and Dentofacial Deformities Centre for Dental Education and Research, All India Institute of Medical Sciences, New Delhi, India.

Special Care in Dentistry : Official Publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry
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This summary is machine-generated.

Binder

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Area of Science:

  • Craniofacial anomalies
  • Medical genetics

Background:

  • Binder's syndrome (BS) presents classical features, but diagnostic and treatment challenges are under-reported.
  • A comprehensive review of BS literature is needed to address these gaps.

Purpose of the Study:

  • To review the literature on Binder's syndrome (BS).
  • To explore diagnostic and treatment challenges in BS.
  • To evaluate the role of a multidisciplinary approach in managing BS.

Main Methods:

  • A systematic literature search was conducted across major scientific databases.
  • Keywords included "Maxillonasal dysplasia", "Binder syndrome", and "OMIM 155050".
  • English-language articles published until June 2021 were reviewed.

Main Results:

  • 145 relevant articles were selected from 958 publications.
  • Most studies were case reports (42%) or case series (19%).
  • Surgical techniques were the most frequently discussed topic (42%).

Conclusions:

  • A multidisciplinary approach is crucial for managing Binder's syndrome.
  • Further research is needed to establish clinical guidelines for BS management.