Related Experiment Video
Updated: Sep 21, 2025
Author Spotlight: Studying Neuromuscular Responses and Motor Neuron Plasticity in Neurodegenerative Diseases
Published on: April 19, 2024
Changes in phrenic nerve compound muscle action potential in streptozotocin-induced diabetic rats
Marcelo C Ferrari1, João V Peixoto1, Rosalvo H Fogaça1
1Laboratory of Cardiovascular Physiology and Pathophysiology, Department of Physiology, Federal University of Paraná, Brazil.
Purpose:
To evaluate the phrenic nerve compound muscle action potential (CMAP) in rats after diabetes mellitus (DM) induction.
Methods:
Twenty DM animals (intravenous streptozotocin, 45 mg.kg-1) and 25 controls underwent CMAP analysis before and 30, 60 and 90 days after DM induction.
Results:
Amplitude (mV) progressively declined in DM group after 30 (Mean difference (MD): -0.915, 95 % Confidence interval (CI) -1.580 to -0.250, p < 0.01), 60 (MD: -1.122, 95 % CI -1.664 to -0.581, p < 0.001) and 90 days (MD: -2.226, 95 % CI -3.059 to -1.393, p < 0.001); as well as the area (mV.ms) after 30 (MD: -3.19, 95 % CI -5.94 to -0.44, p < 0.05), 60 (MD: -3.94, 95 % CI -6.24 to -1.64, p < 0.001) and 90 days (MD: -8.64, 95 % CI -12.08 to -5.21, p < 0.001). Transient differences were observed in latency and duration at 60 days.
Conclusions:
The progressive changes in phrenic nerve CMAP observed during DM suggest a decrement in axonal function rather than substantial demyelination.
