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Updated: Sep 21, 2025

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Published on: June 4, 2021
Plasma Thrombomodulin Levels and Ischemic Stroke: A Population-Based Prognostic Cohort Study
Zhengbao Zhu1, Daoxia Guo2, Yiming Jia2
1From the Department of Epidemiology (Z.Z., D.G., Y.J., K.Z., M.S., P.Y., A.W., T.X., Y.Z.), School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Suzhou Medical College of Soochow University, China; Department of Epidemiology (Z.Z., M.S., J.C., J.H.), Tulane University School of Public Health and Tropical Medicine, New Orleans, LA; Department of Neurology (Y.P.), Affiliated Hospital of North China University of Science and Technology, Hebei; Department of Medicine (J.C., J.H.), Tulane University School of Medicine, New Orleans, LA; and Department of Neurology (J.Z.), the 960th Hospital of People's Liberation Army, Shandong, China. yhzhang@suda.edu.cn.
Higher plasma thrombomodulin levels were linked to better outcomes in ischemic stroke patients. This suggests thrombomodulin may offer protection against stroke complications and disability.
Area of Science:
- Biomedical research
- Cardiovascular science
- Neurology
Background:
- Thrombomodulin possesses anticoagulant, anti-inflammatory, and cytoprotective properties relevant to ischemic stroke.
- Its precise role in stroke outcomes requires further investigation.
Purpose of the Study:
- To examine the association between plasma thrombomodulin levels and clinical outcomes in ischemic stroke patients.
- To determine if thrombomodulin levels predict prognosis after acute ischemic stroke.
Main Methods:
- A multicenter prognostic cohort study involving 3,532 Chinese patients with acute ischemic stroke.
- Follow-up at 3 months to assess the primary outcome (death or major disability) and secondary outcomes.
- Multivariate adjustment and spline regression models were used to analyze data.
Main Results:
- Elevated plasma thrombomodulin levels were associated with a reduced risk of the primary composite outcome (death or major disability) and major disability.
- Higher thrombomodulin levels correlated with a better distribution of modified Rankin Scale scores.
- A linear relationship was observed between plasma thrombomodulin and reduced risk of adverse outcomes.
Conclusions:
- Increased plasma thrombomodulin levels at baseline are associated with improved clinical outcomes at 3 months post-ischemic stroke.
- Thrombomodulin may play a protective role in the context of ischemic stroke.
- Further validation in diverse populations is recommended.
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