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Updated: Sep 21, 2025

Dynamic Inter-subject Functional Connectivity Reveals Moment-to-Moment Brain Network Configurations Driven by Continuous or Communication Paradigms

Dynamic Inter-subject Functional Connectivity Reveals Moment-to-Moment Brain Network Configurations Driven by Continuous or Communication Paradigms

Published on: March 21, 2019

Time-resolved structure-function coupling in brain networks.

Zhen-Qi Liu¹, Bertha Vázquez-Rodríguez¹, R Nathan Spreng¹

¹McConnell Brain Imaging Centre, Montréal Neurological Institute, McGill University, Montréal, Canada.

Communications Biology

|June 2, 2022

Summary

This summary is machine-generated.

Brain connectivity is not static; dynamic, region-specific patterns reveal how structure and function interact over time. This research highlights regional differences in brain networks, offering new insights into neural dynamics.

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Last Updated: Sep 21, 2025

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Area of Science:

Systems Neuroscience
Neuroimaging
Computational Neuroscience

Background:

The brain's structure-function relationship is crucial for understanding neural processing.
Current models often assume a static, global coupling between brain structure and function.
Investigating the dynamic nature of this relationship is essential for a comprehensive understanding.

Purpose of the Study:

To explore the dynamic nature of structure-function coupling in the brain.
To determine if structure-function coupling is regionally heterogeneous.
To identify factors influencing the variability of structure-function coupling.

Main Methods:

Utilized a temporal unwrapping procedure to analyze moment-to-moment neural activity co-fluctuations.
Reconstructed time-resolved patterns of structure-function coupling.
Examined the relationship between connection length distribution and coupling variability.

Main Results:

Structure-function coupling is regionally heterogeneous, not a single global pattern.
Stable coupling observed in unimodal and transmodal cortex.
Dynamic coupling identified in intermediate regions, notably the insular cortex (salience network) and frontal eye fields (dorsal attention network).
Variability in a region's coupling correlates with its connection length distribution.

Conclusions:

Brain structure-function coupling exhibits dynamic and region-specific characteristics.
The findings challenge the notion of a persistent, global structure-function relationship.
Dynamic analysis provides a novel framework for studying brain connectivity and its relationship to neural activity.