Translating Microbiome Research From and To the Clinic
Zhenrun J Zhang1, Christopher J Lehmann2, Cody G Cole1,3
1Duchossois Family Institute, University of Chicago, Chicago, Illinois, USA.
Annual Review of Microbiology
|June 2, 2022
Summary
The gut microbiota significantly impacts human health, influencing disease susceptibility and resistance. Emerging research explores manipulating the gut microbiome for therapeutic benefits, bridging the gap between lab discoveries and clinical applications.
Area of Science:
- Microbiology
- Human Health
- Disease Research
Background:
- The gut microbiota plays a crucial role in maintaining human health.
- Extensive research links gut microbial composition to various diseases.
- Understanding this connection is vital for medical advancements.
Purpose of the Study:
- To review current clinical and laboratory studies on the gut microbiota and human diseases.
- To highlight translational research on microbiome manipulation for disease treatment.
- To discuss challenges and opportunities in clinical microbiome research.
Main Methods:
- Review of recent clinical studies.
- Analysis of laboratory-based experimental research.
- Examination of translational studies on microbiome therapeutics.
Main Results:
- The gut microbiota is strongly associated with numerous human diseases.
- Therapeutic manipulation of the gut microbiota shows promise.
- Translational research is advancing microbiome-based treatments.
Conclusions:
- The gut microbiota is a key factor in health and disease.
- Microbiome-targeted therapies offer new treatment avenues.
- Further research is needed to overcome challenges in clinical translation.
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