Expression of Vincristin-induced Peripheral Neuropathy Related to Different Administration Methods

Area of Science:

• Oncology
• Pharmacology
• Neurology

Background:

• Vincristine (VCR) is a key component of R-CHOP chemotherapy for non-Hodgkin's lymphoma.
• Peripheral neuropathy is a known side effect of vincristine treatment.
• The impact of VCR administration method on neuropathy incidence requires further investigation.

Purpose of the Study:

• To compare the incidence of VCR-induced peripheral neuropathy between rapid intravenous infusion and intravenous drip infusion.
• To evaluate if administration method influences the severity and management of VCR-induced peripheral neuropathy.

Main Methods:

• Retrospective analysis of 71 patients receiving six or more R-CHOP courses.
• Data collected from January 2015 to December 2016 at two hospitals.
• Comparison of peripheral neuropathy rates and severity based on VCR administration method (rapid infusion vs. drip infusion).

Main Results:

• Overall peripheral neuropathy incidence was high and similar between rapid infusion (69%) and drip infusion (75%) groups (P=0.79).
• Most cases in both groups experienced Grade 1 or 2 neuropathy.
• Grade 3 neuropathy, dose reductions, and treatment discontinuations were more frequent with rapid intravenous infusion.

Conclusions:

• While overall neuropathy frequency is similar, intravenous drip infusion of VCR may reduce the occurrence of severe neuropathy (Grade 3).
• Intravenous drip infusion appears to lower the need for VCR dose reduction or discontinuation compared to rapid infusion.
• This study highlights the importance of considering VCR administration method to mitigate severe adverse events.