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Roles and Mechanisms of Regulated Necrosis in Corneal Diseases: Progress and Perspectives

Wanying Lin1, Minting Chen1, Yacouba Cissé1

  • 1Department of Ophthalmology, Nanfang Hospital, Southern Medical University, Guangzhou, China.

Journal of Ophthalmology
|June 3, 2022
PubMed

Insights

Regulated necrosis, including pyroptosis, necroptosis, and ferroptosis, drives corneal disease by damaging cells and increasing inflammation. Understanding these cell death pathways is key to managing corneal conditions.

Area of Science:

  • Cell biology
  • Ophthalmology
  • Pathology

Background:

  • Regulated necrosis involves cell membrane breakdown and cytoplasmic release.
  • It contributes to diseases like stroke, liver disease, hypertension, and cancer.
  • Pyroptosis, necroptosis, and ferroptosis are implicated in corneal disease pathogenesis.

Purpose of the Study:

  • To review molecular mechanisms of pyroptosis, necroptosis, and ferroptosis in corneal diseases.
  • To discuss the role of regulated necrosis in corneal inflammation, repair, and disease outcomes.

Main Methods:

  • Literature review of molecular mechanisms.
  • Analysis of regulated necrosis pathways in corneal disease models.
  • Discussion of clinical implications for corneal disease management.

Main Results:

  • Regulated necrosis exacerbates corneal inflammation and disease progression.
  • Specific pathways like pyroptosis, necroptosis, and ferroptosis contribute uniquely to corneal pathology.
  • These cell death mechanisms impact tissue repair and overall disease outcomes.

Conclusions:

  • Targeting regulated necrosis pathways offers potential therapeutic strategies for corneal diseases.
  • Further research into these cell death mechanisms can improve treatment and patient outcomes.

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