Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Effect of aortic constriction on the functional border zone.

K P Gallagher, X H Ning, R A Gerren

    The American Journal of Physiology
    |April 1, 1987
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    [Clinical characteristics of patients with indication of cardiac implantable electronic devices implantation complicating with acute pulmonary thromboembolism].

    Zhonghua xin xue guan bing za zhi·2020
    Same author

    [Effects of NOX4 on radiosensitivity of nasopharyngeal carcinoma cells by activating the PI3K/AKT pathway].

    Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery·2020
    Same author

    [Phyllodes tumor of the breast with heart and lung metastases: a case report].

    Zhonghua nei ke za zhi·2020
    Same author

    AKT-GSK3<i>β</i> Signaling Pathway Regulates Mitochondrial Dysfunction-Associated OPA1 Cleavage Contributing to Osteoblast Apoptosis: Preventative Effects of Hydroxytyrosol.

    Oxidative medicine and cellular longevity·2019
    Same author

    [Clinical value of fluorescence in situ hybridization positive of exfoliated urothelial cells in urothelial carcinoma].

    Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences·2017
    Same author

    [Concurrent renal cell carcinoma and urothelial carcinoma: long-term follow-up study of 24 cases].

    Zhonghua yi xue za zhi·2017

    Elevated afterload uniformly affects nonischemic myocardium, not worsening the functional border zone. Systolic wall thickening in nonischemic heart muscle remained unchanged despite increased aortic pressure.

    Area of Science:

    • Cardiovascular Physiology
    • Myocardial Ischemia Research
    • Hemodynamics

    Background:

    • The functional border zone, or nonischemic myocardium adjacent to the perfusion boundary, may be vulnerable to altered mechanical loads.
    • Understanding how increased afterload impacts this region is crucial for managing myocardial dysfunction during cardiac events.

    Purpose of the Study:

    • To investigate the effect of aortic constriction (increased afterload) on systolic wall thickening in the nonischemic myocardium near the perfusion boundary.
    • To determine if elevated afterload exacerbates dysfunction in the functional border zone during coronary occlusion.

    Main Methods:

    • Systolic wall thickening (dWT) was measured using sonomicrometry in eight anesthetized dogs.
    • Myocardial blood flow maps, derived from microsphere data, defined the perfusion boundary (PB).

    Related Experiment Videos

  • Aortic constriction was induced to increase peak systolic pressure by approximately 50%.

    • Main Results:

    • In nonischemic myocardium >10 mm from the PB, dWT significantly increased during coronary occlusion alone.
    • Within 10 mm of the PB, dWT showed no significant change during occlusion.
    • Aortic constriction caused a similar relative decrease in dWT in both regions (<10 mm and >10 mm from PB), indicating uniform effects.

    Conclusions:

    • Elevated afterload affects nonischemic myocardium uniformly, regardless of proximity to the perfusion boundary.
    • Increased afterload does not significantly increase the size or relative severity of the functional border zone during coronary occlusion.
    • The functional border zone's extent of dysfunction was not significantly altered by the tested increase in afterload.