Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Desensitization and Tachyphylaxis01:20

Desensitization and Tachyphylaxis

2.3K
Tachyphylaxis is described as a rapid decrease in response to a drug after repeated or continuous administration of the same drug dose. It is a phenomenon where the body becomes less responsive to a particular substance or intervention over time, requiring higher doses or stronger interventions to achieve the same effect. It results from adaptive changes in the body's receptors, signaling pathways, or physiological processes that occur in response to prolonged exposure to a stimulus.
2.3K
Tumor Progression02:07

Tumor Progression

6.5K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
6.5K
Generation Time01:22

Generation Time

394
Bacterial generation time, the period required for a bacterial population to double during its exponential growth phase, serves as a critical measure of microbial growth dynamics under optimal conditions. This parameter varies significantly across bacterial species and can be influenced by factors such as temperature, pH, and the availability of nutrients. For example, Escherichia coli can achieve a generation time of approximately 20 minutes, while Mycobacterium tuberculosis exhibits a much...
394
Reason and Intuition01:37

Reason and Intuition

6.9K
The human brain processes information for decision-making using one of two routes: an intuitive system and a rational system (Epstein, 1994; popularized by Kahneman, 2011 as System 1 and System 2, respectively). The intuitive system is quick, impulsive, and operates with minimal effort, relying on emotions or habits to provide cues for what to do next, while the rational system is logical, analytical, deliberate, and methodical. Research in neuropsychology suggests that the...
6.9K
Time-Domain Interpretation of PD Control01:07

Time-Domain Interpretation of PD Control

186
Proportional-Derivative (PD) control is a widely used control method in various engineering systems to enhance stability and performance. In a system with only proportional control, common issues include high maximum overshoot and oscillation, observed in both the error signal and its rate of change. This behavior can be divided into three distinct phases: initial overshoot, subsequent undershoot, and gradual stabilization.
Consider the example of control of motor torque. Initially, a positive...
186
Propagation of Uncertainty from Random Error00:59

Propagation of Uncertainty from Random Error

1.1K
An experiment often consists of more than a single step. In this case, measurements at each step give rise to uncertainty. Because the measurements occur in successive steps, the uncertainty in one step necessarily contributes to that in the subsequent step. As we perform statistical analysis on these types of experiments, we must learn to account for the propagation of uncertainty from one step to the next. The propagation of uncertainty depends on the type of arithmetic operation performed on...
1.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Lurking Danger: Emerging Evidence.

Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine·2024
Same author

ISCCM Guidelines on Acute Kidney Injury and Renal Replacement Therapy.

Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine·2023
Same author

Competencies for Point-of-care Ultrasonography in ICU: An ISCCM Expert Panel Practice Recommendation.

Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine·2023
Same author

Recommendations for Evaluation and Selection of Deceased Organ Donor: Position Statement of ISCCM.

Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine·2023

Related Experiment Video

Updated: Sep 21, 2025

A Suppressor Screen for the Characterization of Genetic Links Regulating Chronological Lifespan in Saccharomyces cerevisiae
10:39

A Suppressor Screen for the Characterization of Genetic Links Regulating Chronological Lifespan in Saccharomyces cerevisiae

Published on: September 17, 2020

6.4K

Providencial Progression: Time to be Intolerant.

Palepu Gopal1

  • 1Citizen Hospitals, Hyderabad, Telangana, India.

Indian Journal of Critical Care Medicine : Peer-Reviewed, Official Publication of Indian Society of Critical Care Medicine
|June 3, 2022
PubMed
Summary
This summary is machine-generated.

This article argues for a more critical and intolerant approach to certain medical practices and research. It emphasizes the need for rigorous standards to ensure patient safety and scientific integrity in critical care medicine.

Keywords:
AcinetobacterCatheter-associated urinary tract infectionsCritically illKlebsiella pneumoniaeProvidencia

More Related Videos

Studying Age-dependent Genomic Instability using the S. cerevisiae Chronological Lifespan Model
08:46

Studying Age-dependent Genomic Instability using the S. cerevisiae Chronological Lifespan Model

Published on: September 29, 2011

15.7K
The Power of Interstimulus Interval for the Assessment of Temporal Processing in Rodents
10:27

The Power of Interstimulus Interval for the Assessment of Temporal Processing in Rodents

Published on: April 19, 2019

7.1K

Related Experiment Videos

Last Updated: Sep 21, 2025

A Suppressor Screen for the Characterization of Genetic Links Regulating Chronological Lifespan in Saccharomyces cerevisiae
10:39

A Suppressor Screen for the Characterization of Genetic Links Regulating Chronological Lifespan in Saccharomyces cerevisiae

Published on: September 17, 2020

6.4K
Studying Age-dependent Genomic Instability using the S. cerevisiae Chronological Lifespan Model
08:46

Studying Age-dependent Genomic Instability using the S. cerevisiae Chronological Lifespan Model

Published on: September 29, 2011

15.7K
The Power of Interstimulus Interval for the Assessment of Temporal Processing in Rodents
10:27

The Power of Interstimulus Interval for the Assessment of Temporal Processing in Rodents

Published on: April 19, 2019

7.1K

Area of Science:

  • Critical Care Medicine
  • Medical Ethics
  • Scientific Rigor

Background:

  • The article discusses the importance of maintaining high standards in critical care.
  • It highlights the potential risks associated with complacency in medical research and practice.

Discussion:

  • The author advocates for a proactive and "intolerant" stance against substandard or unproven medical interventions.
  • This approach is framed as essential for safeguarding patient well-being and advancing evidence-based medicine.

Key Insights:

  • A critical and "intolerant" approach is necessary to uphold scientific integrity.
  • Upholding rigorous standards is paramount in critical care medicine to prevent harm.
  • Continuous evaluation and rejection of non-evidence-based practices are crucial.

Outlook:

  • Future directions should focus on strengthening quality control mechanisms in medical research.
  • Promoting a culture of critical inquiry and intolerance towards scientific mediocrity is vital.
  • The article calls for a paradigm shift towards more stringent evaluation of medical practices.