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Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation
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Vascular Calcification in Chronic Kidney Disease: An Update and Perspective

Si-Chong Ren1,2,3, Nan Mao1,2, Si Yi1,4

  • 11Chengdu Medical College, Chengdu, China.

Aging and Disease
|June 3, 2022
PubMed

Insights

Chronic kidney disease (CKD) accelerates vascular calcification, increasing cardiovascular risks. This review details CKD

Area of Science:

  • Nephrology
  • Cardiovascular Medicine
  • Vascular Biology

Background:

  • Chronic kidney disease (CKD) leads to irreversible nephron loss and mineral disorders.
  • Vascular calcification (VC), a common complication in CKD, significantly elevates cardiovascular morbidity and mortality.
  • Aging and metabolic disorders are key risk factors for both CKD and VC.

Purpose of the Study:

  • To systematically review the mechanisms of VC in CKD.
  • To elucidate the impact of CKD on VC pathophysiology.
  • To summarize diagnostic biomarkers and therapeutic strategies for VC in CKD.

Main Methods:

  • Systematic literature review.
  • Analysis of underlying mechanisms of vascular calcification in CKD.
  • Evaluation of diagnostic biomarkers and therapeutic applications.

Main Results:

  • CKD significantly contributes to the pathophysiology of vascular calcification.
  • Several potential clinical diagnostic biomarkers for VC in CKD have been identified.
  • Emerging therapeutic strategies show promise for managing VC in CKD patients.

Conclusions:

  • Understanding VC mechanisms in CKD is crucial for improving patient outcomes.
  • Further research into diagnostic biomarkers and novel therapies is warranted.
  • This review provides insights into the pathogenesis, diagnosis, and treatment of VC in CKD.

Keywords:
agingbiomarkerchronic kidney diseasemetabolismvascular calcification

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