Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Colloids03:22

Colloids

18.0K
Children at play often make suspensions such as mixtures of mud and water, flour and water, or a suspension of solid pigments in water known as tempera paint. These suspensions are heterogeneous mixtures composed of relatively large particles that are visible to the naked eye or can be seen with a magnifying glass. They are cloudy, and the suspended particles settle out after mixing. On the other hand, a solution is a homogeneous mixture in which no settling occurs and in which the dissolved...
18.0K
Noncovalent Attractions in Biomolecules02:35

Noncovalent Attractions in Biomolecules

18.5K
18.5K
Intermolecular Forces in Solutions02:28

Intermolecular Forces in Solutions

34.9K
The formation of a solution is an example of a spontaneous process, a process that occurs under specified conditions without energy from some external source.
When the strengths of the intermolecular forces of attraction between solute and solvent species in a solution are no different than those present in the separated components, the solution is formed with no accompanying energy change. Such a solution is called an ideal solution. A mixture of ideal gases (or gases such as helium and argon,...
34.9K
Colloidal precipitates01:09

Colloidal precipitates

782
The high insolubility of some precipitates can result in an unfavorable relative supersaturation. This can lead to colloidal particles with a large surface-to-mass ratio, where adsorption is promoted. For instance, in the precipitation of silver chloride, silver ions are adsorbed on the surface of the colloidal particles, forming a primary layer. This layer attracts ions of opposite charge (such as nitrate ions), forming a diffuse secondary layer of adsorbed ions. This electric double layer...
782
Cationic Chain-Growth Polymerization: Mechanism00:57

Cationic Chain-Growth Polymerization: Mechanism

2.4K
The cationic polymerization mechanism consists of three steps: initiation, propagation, and termination. In the initiation step of the polymerization process, the π bond of a monomer gets protonated by the Lewis acid catalyst, which is formed from boron trifluoride and water. The protonation of the π bond generates a carbocation stabilized by the electron‐donating group. In the propagation step, the π bond of the second monomer acts as a nucleophile and attacks the...
2.4K
Mechanisms of Membrane Domain Formation00:59

Mechanisms of Membrane Domain Formation

3.2K
Different physical properties of lipids and proteins allow them to localize and form distinct islands or domains in the membrane. Some membrane domains are formed due to protein-protein interactions, whereas others are formed due to the presence of specific lipids such as sphingolipids and sterols—for example, large proteins, such as bacteriorhodopsin, aggregate and create distinct domains.
Another mechanism for membrane domain formation involves membrane proteins interacting with...
3.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Sortase A-Mediated Farnesylation of Cdc42 <i>In Vitro</i>.

ACS synthetic biology·2026
Same author

The role of ionizing radiation-initiated reactions in targeted activation of chemotherapeutics.

Nature reviews. Chemistry·2025
Same author

Organochloride mediated prodrug activation induced by ionizing radiation.

Chemical science·2025
Same author

Nucleophile-triggered prodrug release from polymer hydrogels.

RSC applied polymers·2025
Same author

Alkyl Chloride-Functionalized Polymers Mediate Oxidation of Thioethers Initiated by Ionizing Radiation.

ACS applied polymer materials·2025
Same author

Naked-Eye Thiol Analyte Detection via Self-Propagating, Amplified Reaction Cycle.

Journal of the American Chemical Society·2023

Related Experiment Video

Updated: Sep 21, 2025

Assembly and Characterization of Polyelectrolyte Complex Micelles
08:44

Assembly and Characterization of Polyelectrolyte Complex Micelles

Published on: March 2, 2020

11.0K

Fuel-driven macromolecular coacervation in complex coacervate core micelles.

Reece W Lewis1, Benjamin Klemm1, Mariano Macchione1

  • 1Department of Chemical Engineering, Delft University of Technology Van der Maasweg 9 2629 HZ Delft The Netherlands R.Eelkema@tudelft.nl.

Chemical Science
|June 3, 2022
PubMed
Summary

Researchers developed a chemical reaction network to control macromolecular coacervation, enabling transient material phases. This method allows for precise, signal-responsive assembly and disassembly of complex coacervate core micelles at physiological pH.

More Related Videos

Fabrication of Spherical and Worm-shaped Micellar Nanocrystals by Combining Electrospray, Self-assembly, and Solvent-based Structure Control
06:16

Fabrication of Spherical and Worm-shaped Micellar Nanocrystals by Combining Electrospray, Self-assembly, and Solvent-based Structure Control

Published on: February 11, 2018

14.0K
ECM Protein Nanofibers and Nanostructures Engineered Using Surface-initiated Assembly
16:33

ECM Protein Nanofibers and Nanostructures Engineered Using Surface-initiated Assembly

Published on: April 17, 2014

12.6K

Related Experiment Videos

Last Updated: Sep 21, 2025

Assembly and Characterization of Polyelectrolyte Complex Micelles
08:44

Assembly and Characterization of Polyelectrolyte Complex Micelles

Published on: March 2, 2020

11.0K
Fabrication of Spherical and Worm-shaped Micellar Nanocrystals by Combining Electrospray, Self-assembly, and Solvent-based Structure Control
06:16

Fabrication of Spherical and Worm-shaped Micellar Nanocrystals by Combining Electrospray, Self-assembly, and Solvent-based Structure Control

Published on: February 11, 2018

14.0K
ECM Protein Nanofibers and Nanostructures Engineered Using Surface-initiated Assembly
16:33

ECM Protein Nanofibers and Nanostructures Engineered Using Surface-initiated Assembly

Published on: April 17, 2014

12.6K

Area of Science:

  • Polymer Chemistry
  • Materials Science
  • Supramolecular Chemistry

Background:

  • Macromolecular coacervation forms transient, highly charged material phases.
  • Dynamic coacervates often require complex biomolecules or non-physiological conditions.
  • Radical polymerization offers accessible routes to functional macromolecular precursors.

Purpose of the Study:

  • To establish a fuel-driven chemical reaction network (CRN) for controlled macromolecular coacervation.
  • To demonstrate signal-responsive assembly and disassembly of complex coacervate core micelles (C3Ms).
  • To achieve dynamic coacervate behavior at physiological pH without complex biomolecules.

Main Methods:

  • Utilized a CRN involving tertiary amine substrates and electron-deficient allyl acetates with thiol/amine nucleophiles.
  • Incorporated tertiary amine functionality into block copolymers.
  • Investigated the effect of varying fuel, nucleophile, and reagent ratios on C3M formation and dissociation.

Main Results:

  • Demonstrated CRN-driven transient quaternization for coacervation.
  • Achieved chemically triggered C3M assembly and disassembly using block copolymers.
  • Showcased sequential and transient non-equilibrium C3M (dis)assembly at constant physiological pH.

Conclusions:

  • Developed a novel CRN for tunable, fuel-driven macromolecular coacervation.
  • Established a system for timed and signal-responsive C3M formation/dissolution under physiological conditions.
  • Highlighted potential applications in nucleic acid delivery, nanoreactors, and protocell research.