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Correlation between Serum 25-Hydroxy Vitamin D Levels and the Severity of Acne Vulgaris: A Systematic Review
Shinta D Rasti1, Nena R Dewinta1, Ronik H Kamal1
1Department of Public Health and Preventive Medicine, Faculty of Medicine, Airlangga University, Kota SBY, Jawa Timur, Indonesia.
Background:
Vitamin D is thought to play a role in the pathogenesis of acne, and its levels can change in patients with acne vulgaris. Several studies have revealed that serum 25-hydroxy vitamin D levels tend to be low and statistically significant in acne vulgaris patients. However, the relationship between vitamin D levels and acne severity is still poorly understood.
Objective:
This study aims to identify the correlation between serum 25-hydroxy vitamin D levels and the severity of acne vulgaris.
Method:
This systematic review study was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guideline based on several studies taken from the PubMed, PMC, Semantic Scholar, and ResearchGate databases until June 2021. Full-text case-control, randomized controlled trial, or cross-sectional study in English or Indonesian language reporting on the serum 25-hydroxy vitamin D levels and the severity of acne vulgaris on human participants were included.
Result:
From a total of 401 studies, 10 studies met the criteria. Almost all studies (8 of 10) revealed lower serum 25-hydroxy vitamin D levels as the acne severity progresses, although 2 of them were not statistically significant.
Conclusion:
The evidence of an inverse correlation between serum 25-hydroxy vitamin D levels and the severity of acne vulgaris suggests the need for screening of vitamin D levels in acne patients and offers a new prospect in the field of acne prevention and treatment.
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