Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drug-Receptor Interactions01:29

Drug-Receptor Interactions

6.1K
Drug-receptor interaction describes the binding of receptors by drugs, but not all drug-receptor interactions result in activation and tissue response. For instance, the binding of agonists activates the receptor to generate a cellular reaction, while antagonists bind to receptors without causing their activation.
Several parameters, such as the drug's affinity for its receptor and its efficacy, which is its ability to activate the receptor, determine the drug's effect on the tissue....
6.1K
Drug Discovery: Overview01:26

Drug Discovery: Overview

8.8K
Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...
8.8K
Targets for Drug Action: Overview01:26

Targets for Drug Action: Overview

7.6K
Drugs target macromolecules to modify ongoing cellular processes. Primary drug targets include receptors, ion channels, transporters, and enzymes.
Receptors are either membrane-spanning or intracellular proteins, which upon binding a ligand, get activated and transmit the signal downstream to elicit a response. Drugs bind receptors, either mimicking the action of endogenous ligands or blocking the receptor activity to bring about a modified response. Nearly 35% of approved drugs target the G...
7.6K
Principles of Drug Action01:24

Principles of Drug Action

6.7K
Drugs are chemical substances that modify biological responses by interacting with macromolecular targets such as receptors, ion channels, transporters, and enzymes. Pharmacodynamics describes the course of action of drugs leading to the physiological effect at a specific site in the body.
Drugs can be agonists or antagonists. Like the endogenous ligands, agonists always bind and activate the target to produce a cellular response. Agonist binding induces a conformational change which in turn...
6.7K
Combined Effects of Drugs: Antagonism01:30

Combined Effects of Drugs: Antagonism

9.4K
The combined effects of drugs can result in various interactions, of which an important type is antagonism. Antagonism is a mechanism where one drug inhibits or counteracts the effects of another drug. Antagonism can occur through various means, including receptor binding, allosteric modulation, functional interaction, chemical reactions, and pharmacokinetic processes.
The most common type is receptor antagonism, where one drug acts as an antagonist to block the effects of another drug by...
9.4K
Neurochemical Transmission: Sites of Drug Action01:26

Neurochemical Transmission: Sites of Drug Action

2.7K
Neurochemical transmission, the conduction of electrical impulses between neurons mediated by neurotransmitters, plays a vital role in various physiological processes. Autonomic drugs exert their effects by modulating neurotransmission within the autonomic nervous system. For instance, drugs such as hemicholinium block the precursor uptake necessary for synthesizing acetylcholine, an essential autonomic neurotransmitter. Following synthesis, neurotransmitters are stored in vesicles. Metyrosine...
2.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comprehensive analysis of the RBP regulome reveals functional modules and drug candidates in liver cancer.

Scientific reports·2026
Same author

GeneSNAKE: a Python package for simulation of gene regulatory networks and perturbation-induced expression data.

Bioinformatics advances·2026
Same author

Quest for Orthologs in the era of Data Deluge and AI: Challenges and Innovations in Orthology Prediction and Data Integration.

Journal of molecular evolution·2025
Same author

BiGSM: Bayesian inference of gene regulatory network via sparse modelling.

Bioinformatics (Oxford, England)·2025
Same author

Topology-based metrics for finding the optimal sparsity in gene regulatory network inference.

Bioinformatics (Oxford, England)·2025
Same author

The FunCoup Cytoscape App: multi-species network analysis and visualization.

Bioinformatics (Oxford, England)·2024

Related Experiment Video

Updated: Sep 21, 2025

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System
05:10

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System

Published on: December 11, 2016

9.7K

Corrigendum: Network Crosstalk as a Basis for Drug Repurposing.

Dimitri Guala1,2, Erik L L Sonnhammer1

  • 1Department of Biochemistry and Biophysics, Stockholm University, Science for Life Laboratory, Solna, Sweden.

Frontiers in Genetics
|June 3, 2022
PubMed
Summary

This study corrects a previous article DOI. The corrected article focuses on genetic research and its applications.

Keywords:
benchmarkdrug repositioningdrug repurposingfunctional association networknetwork crosstalknetwork-basedshortest path

More Related Videos

Chemogenetic Regulation in Reprogrammed Stem Cell-derived Precursor Cells in Treating Neurodegenerative Diseases
09:44

Chemogenetic Regulation in Reprogrammed Stem Cell-derived Precursor Cells in Treating Neurodegenerative Diseases

Published on: May 2, 2025

331
High-throughput Identification of Synergistic Drug Combinations by the Overlap2 Method
07:51

High-throughput Identification of Synergistic Drug Combinations by the Overlap2 Method

Published on: May 21, 2018

12.0K

Related Experiment Videos

Last Updated: Sep 21, 2025

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System
05:10

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System

Published on: December 11, 2016

9.7K
Chemogenetic Regulation in Reprogrammed Stem Cell-derived Precursor Cells in Treating Neurodegenerative Diseases
09:44

Chemogenetic Regulation in Reprogrammed Stem Cell-derived Precursor Cells in Treating Neurodegenerative Diseases

Published on: May 2, 2025

331
High-throughput Identification of Synergistic Drug Combinations by the Overlap2 Method
07:51

High-throughput Identification of Synergistic Drug Combinations by the Overlap2 Method

Published on: May 21, 2018

12.0K

Area of Science:

  • Genetics
  • Bioinformatics
  • Genomics

Context:

  • The study addresses a correction to a previously published article's digital object identifier (DOI).
  • Ensuring accurate citation and access to genetic research is crucial for scientific integrity.

Purpose:

  • To provide the correct DOI for the article '[10.3389/fgene.2022.792090.]'.
  • To ensure readers can access the intended genetic research findings accurately.

Summary:

  • A correction has been issued for the article with DOI 10.3389/fgene.2022.792090.
  • This ensures proper attribution and access to the genetic research presented.

Impact:

  • Facilitates accurate referencing and retrieval of genetic research data.
  • Maintains the integrity of the scientific record and aids future research endeavors.