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Updated: Sep 21, 2025

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The chemistry and biology of natural ribomimetics and related compounds

Takeshi Tsunoda1, Samuel Tanoeyadi1, Philip J Proteau1

  • 1Department of Pharmaceutical Sciences, Oregon State University Corvallis OR 97331 USA Taifo.Mahmud@oregonstate.edu.

RSC Chemical Biology
|June 3, 2022
PubMed

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Nucleic acid biosynthesis is a fundamental biochemical process that produces the purine and pyrimidine nucleotides essential for DNA and RNA synthesis. This pathway maintains a balanced nucleotide pool, preventing imbalances that could jeopardize genetic integrity and cellular function. Given the crucial role of nucleotides, their synthesis is tightly regulated to ensure proper cellular homeostasis.Purine BiosynthesisThe biosynthesis of purine nucleotides begins with ribose-5-phosphate, a...
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