Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Author Correction: Injured epithelial cell states impact kidney allograft survival after T-cell-mediated rejection.

Nature communications·2026
Same author

Injured epithelial cell states impact kidney allograft survival after T-cell-mediated rejection.

Nature communications·2026
Same author

The dorsal aortic compartment is a developmental source of brown adipose tissue in mice.

Nature communications·2026
Same author

Astrocytic-OTUD7B ameliorates murine experimental autoimmune encephalomyelitis by stabilizing glial fibrillary acidic protein and preventing inflammation.

Nature communications·2025
Same author

A macrophage-predominant immunosuppressive microenvironment and therapeutic vulnerabilities in advanced salivary gland cancer.

Nature communications·2025
Same author

Establishment of gastrointestinal assembloids to study the interplay between epithelial crypts and their mesenchymal niche.

Nature communications·2023

Related Experiment Video

Updated: Sep 21, 2025

Author Spotlight: Integrating Single-Cell Transcriptomics with Organoid Cultures for Advanced Research and Therapeutic Insights
08:23

Author Spotlight: Integrating Single-Cell Transcriptomics with Organoid Cultures for Advanced Research and Therapeutic Insights

Published on: June 28, 2024

967

Single cell- and spatial 'Omics revolutionize physiology.

Thomas Conrad1, Janine Altmüller1,2,3

  • 1Genomics Technology Platform, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany.

Acta Physiologica (Oxford, England)
|June 3, 2022
PubMed
Summary
This summary is machine-generated.

Single cell multi-omics and spatial transcriptomics offer high-resolution insights into cellular functions. These powerful technologies are revolutionizing the study of health and disease by revealing cellular interactions and tissue architecture.

Keywords:
multi-omicssingle cell technologiesspatial transcriptomics

More Related Videos

Mapping the Emergent Spatial Organization of Mammalian Cells using Micropatterns and Quantitative Imaging
09:56

Mapping the Emergent Spatial Organization of Mammalian Cells using Micropatterns and Quantitative Imaging

Published on: April 30, 2019

6.7K
Combining Laser Capture Microdissection and Microfluidic qPCR to Analyze Transcriptional Profiles of Single Cells: A Systems Biology Approach to Opioid Dependence
09:54

Combining Laser Capture Microdissection and Microfluidic qPCR to Analyze Transcriptional Profiles of Single Cells: A Systems Biology Approach to Opioid Dependence

Published on: March 8, 2020

5.4K

Related Experiment Videos

Last Updated: Sep 21, 2025

Author Spotlight: Integrating Single-Cell Transcriptomics with Organoid Cultures for Advanced Research and Therapeutic Insights
08:23

Author Spotlight: Integrating Single-Cell Transcriptomics with Organoid Cultures for Advanced Research and Therapeutic Insights

Published on: June 28, 2024

967
Mapping the Emergent Spatial Organization of Mammalian Cells using Micropatterns and Quantitative Imaging
09:56

Mapping the Emergent Spatial Organization of Mammalian Cells using Micropatterns and Quantitative Imaging

Published on: April 30, 2019

6.7K
Combining Laser Capture Microdissection and Microfluidic qPCR to Analyze Transcriptional Profiles of Single Cells: A Systems Biology Approach to Opioid Dependence
09:54

Combining Laser Capture Microdissection and Microfluidic qPCR to Analyze Transcriptional Profiles of Single Cells: A Systems Biology Approach to Opioid Dependence

Published on: March 8, 2020

5.4K

Area of Science:

  • Biotechnology
  • Genomics
  • Cell Biology

Background:

  • Single cell multi-omics and spatial transcriptomics are rapidly advancing fields.
  • These technologies provide high-resolution profiling of cellular and molecular functions.
  • Understanding individual cells and their interactions is crucial for studying physiology in health and disease.

Purpose of the Study:

  • To provide a comprehensive overview of single cell and spatial analysis technologies.
  • To discuss the advantages and limitations of various technological approaches.
  • To highlight the impact of these methods through case studies.

Main Methods:

  • Review of technological concepts for single cell analysis.
  • Review of technological concepts for spatial transcriptomics.
  • Analysis of case studies demonstrating applications.

Main Results:

  • Identification of novel approaches for high-resolution omics profiling.
  • Demonstration of the utility of these methods in diverse biological contexts.
  • Highlighting key discoveries in embryonic development, tumor immunology, and tissue architecture.

Conclusions:

  • Single cell and spatial transcriptomics are invaluable tools for biological research.
  • These technologies enable a deeper understanding of complex biological systems.
  • Continued technological innovation promises further breakthroughs in understanding life processes.