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The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
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Cutaneous reactive B-cell lymphoid proliferations.

Shadi Khalil1, Deepak Donthi2, Alejandro A Gru3

  • 1Department of Dermatology, University of California San Diego, San Diego, California, USA.

Journal of Cutaneous Pathology
|June 3, 2022
PubMed
Summary
This summary is machine-generated.

Cutaneous lymphoid hyperplasia (CLH) involves benign B- and T-cell infiltrates in the skin. Distinguishing reactive CLH from B-cell lymphomas is crucial for accurate diagnosis and treatment of these skin lesions.

Keywords:
lymphocytic infiltratelymphoid hyperplasiapseudolymphoma

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Area of Science:

  • Dermatology
  • Pathology
  • Immunology

Background:

  • Cutaneous lymphoid hyperplasia (CLH), or cutaneous pseudolymphoma, encompasses benign reactive B- and T-cell infiltrates in the skin.
  • B-cell lymphoid proliferations are diverse and require histopathological differentiation from cutaneous B-cell lymphomas.
  • Reactive CLH can be triggered by infections, medications, allergens, or neoplasms, and is associated with inflammatory conditions.

Purpose of the Study:

  • To review cutaneous B-cell lymphoid proliferations, categorizing them into reactive and disease-associated CLH.
  • To highlight key features for differentiating atypical CLH from cutaneous B-cell lymphomas.
  • To emphasize the importance of understanding B-cell CLH patterns for diagnosis and patient management.

Main Methods:

  • Literature review summarizing B-cell CLH.
  • Discussion of diagnostic criteria for distinguishing benign from malignant lymphoid proliferations.
  • Categorization of CLH based on reactive and disease-associated origins.

Main Results:

  • CLH presents as a spectrum of benign reactive B- and T-cell infiltrates.
  • Various factors can trigger reactive B-cell proliferations, mimicking lymphomas.
  • Specific patterns of B-cell CLH are identified, aiding in differential diagnosis.

Conclusions:

  • Accurate histopathological distinction between reactive CLH and cutaneous B-cell lymphoma is essential.
  • Understanding the diverse causes and presentations of B-cell CLH improves patient care.
  • This review provides a framework for diagnosing and managing patients with cutaneous B-cell lymphoid proliferations.