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Updated: Sep 21, 2025

A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma
Published on: September 30, 2021
The complex management of hepatocellular carcinoma: a major need for expertise
Ana María Matilla1, María Varela2, María Reig3
1Gastroenterology. Liver Unit, Hospital General Universitario Gregorio Marañón, España.
Abstract:
Hepatocellular carcinoma (HCC) is the most frequent liver primary cancer and represents the sixth malignant neoplasm and the fourth cause of cancer associated deaths worldwide. Despite improvements across the last years in therapeutic options, it is still associated with a high mortality. Therefore, HCC represents a major health problem and a challenge for clinicians in terms of management of patient care.
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