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Reactive perforating collagenosis in Hodgkin's disease
The American Journal of Dermatopathology
|February 1, 1987
Summary
Reactive perforating collagenosis may be caused by intense scratching, as seen in two Hodgkin's disease patients. Lesions resolved with disease remission, suggesting a link between pruritus and skin manifestations.
Area of Science:
- Dermatology
- Oncology
Background:
- Reactive perforating collagenosis (RPC) is a rare skin condition.
- RPC has been previously associated with hereditary factors, diabetes, and hemodialysis.
Observation:
- Two patients with Hodgkin's disease presented with severe pruritus leading to vigorous scratching.
- This scratching resulted in the development of skin lesions consistent with RPC.
Findings:
- In one patient, the RPC lesions resolved as Hodgkin's disease went into remission.
- The findings suggest that intense scratching, potentially triggered by underlying conditions, may be a primary cause of RPC.
Implications:
- This challenges the traditional view of RPC as solely hereditary or linked to specific systemic diseases.
- It highlights the potential role of excoriation in the pathogenesis of perforating dermatoses.
- Further research is warranted to explore the relationship between pruritus, scratching, and RPC in various patient populations.