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[Atopic dermatitis : the therapeutic revolution is underway]
Th Damsin1, F Libon1, A F Nikkels1
1Service de Dermatologie, CHU Liège, Belgique.
Revue Medicale De Liege
|June 3, 2022
Summary
Targeted therapies like dupilumab have revolutionized atopic dermatitis treatment since 2017. New options including tralokinumab and JAK inhibitors offer improved clinical outcomes for moderate to severe cases.
Area of Science:
- Dermatology
- Immunology
- Pharmacology
Background:
- Moderate to severe atopic dermatitis treatment has significantly advanced.
- The introduction of targeted therapies marked a paradigm shift in patient care.
Purpose of the Study:
- To review current and emerging therapeutic options for atopic dermatitis.
- To highlight advancements in targeted treatments for moderate to severe atopic dermatitis.
Main Methods:
- Literature review of targeted therapies for atopic dermatitis.
- Analysis of monoclonal antibodies and small molecule inhibitors.
Main Results:
- Dupilumab, a monoclonal antibody targeting interleukins 4 and 13, has shown significant clinical improvement.
- Other agents like tralokinumab and Janus kinase (JAK) inhibitors (e.g., upadacitinib, baricitinib) are now available.
- These targeted therapies represent a new era in managing atopic dermatitis.
Conclusions:
- The therapeutic landscape for atopic dermatitis has been transformed by targeted therapies.
- Patients with moderate to severe atopic dermatitis have more effective treatment options.
- Ongoing research continues to expand the armamentarium against atopic dermatitis.
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