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Updated: Sep 21, 2025

Methods for Evaluating the Role of c-Fos and Dusp1 in Oncogene Dependence
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Published on: January 7, 2019

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CDC7 as a novel biomarker and druggable target in cancer

Runze Liu1, Yong Huang2

  • 1National Center for International Research of Bio-Targeting Theranostics, Guangxi Key Laboratory of Bio-Targeting Theranostics, Collaborative Innovation Center for Targeting Tumor Diagnosis and Therapy, Guangxi Talent Highland of Bio-Targeting Theranostics, Guangxi Medical University, Nanning, 530021, Guangxi, China.

Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
|June 3, 2022
PubMed

Insights

Cell division cycle 7 kinase (CDC7) is crucial for DNA replication and repair. Targeting CDC7 offers a promising strategy for improving cancer treatment and patient prognosis in oncology.

Area of Science:

  • Molecular Biology
  • Oncology
  • Biochemistry

Background:

  • Traditional tumor treatments face limitations, necessitating novel therapeutic targets.
  • Cell division cycle 7 kinase (CDC7) is implicated in DNA replication, repair, and recombination pathways.

Purpose of the Study:

  • To review the role of CDC7 in DNA replication in normal human tissues.
  • To highlight CDC7's function in tumor cell replication stress tolerance and its clinical prognostic impact.
  • To identify and summarize CDC7 inhibitors for future clinical applications.

Main Methods:

  • Literature review of recent studies on CDC7.
  • Integration of evidence on CDC7's role in DNA replication and stress tolerance.
  • Analysis of CDC7 inhibitors in preclinical and clinical research.

Main Results:

  • CDC7 is essential for DNA replication in normal cells.
  • CDC7 inhibition impacts tumor cell replication stress tolerance.
  • CDC7 activity correlates with prognosis in oncology patients.

Conclusions:

  • CDC7 is a critical target for cancer therapy.
  • Understanding CDC7's role can lead to improved treatment strategies.
  • Further research into CDC7 inhibitors holds promise for clinical practice.
Keywords:
CDC7CDC7 inhibitorsCell cyclePrognosisReplication stress

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