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Author Spotlight: Development of a Method for Identifying Small Molecular Antagonists of β2 Integrin Activation
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Integrating intracellular nanovesicles into integrin trafficking pathways and beyond

Gabrielle Larocque1, Stephen J Royle2

  • 1The Francis Crick Institute, Midland Road, London, NW1 1AT, UK.

Cellular and Molecular Life Sciences : CMLS
|June 3, 2022
PubMed

Membrane traffic controls the movement of proteins and lipids from one cellular compartment to another using a system of transport vesicles. Intracellular nanovesicles (INVs) are a newly described class of transport vesicles. These vesicles are small, carry diverse cargo, and are involved in multiple trafficking steps including anterograde traffic and endosomal recycling. An example of a biological process that they control is cell migration and invasion, due to their role in integrin recycling. In this review, we describe what is known so far about these vesicles. We discuss how INVs may integrate into established membrane trafficking pathways using integrin recycling as an example. We speculate where in the cell INVs have the potential to operate and we identify key questions for future investigation.

Keywords:
IntegrinsIntracellular nanovesiclesMembrane traffickingMigrationRab30TPD54

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