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Noninvasive Screening Tool for Hyperkalemia Using a Single-Lead Electrocardiogram and Deep Learning: Development and
Erdenebayar Urtnasan1,2, Jung Hun Lee3, Byungjin Moon2
1Artificial Intelligence Big Data Medical Center, Wonju College of Medicine, Yonsei University, Wonju, Republic of Korea.
Insights
A novel deep learning model using a single-lead electrocardiogram (ECG) can noninvasively screen for hyperkalemia in emergency medicine. This method offers a real-time alternative to blood testing for patients with chronic kidney disease (CKD).
Area of Science:
- Cardiology
- Nephrology
- Artificial Intelligence in Medicine
Background:
- Hyperkalemia monitoring is critical for patients with chronic kidney disease (CKD) in emergency settings.
- Current diagnosis relies on serum potassium levels via blood testing, necessitating a noninvasive, real-time alternative.
- Emergency medicine requires efficient tools for rapid hyperkalemia assessment.
Purpose of the Study:
- To develop a novel, noninvasive method for hyperkalemia screening.
- To utilize a single-lead electrocardiogram (ECG) and deep learning for this purpose.
- To provide a real-time monitoring solution in emergency departments.
Main Methods:
- A deep learning model, comprising convolutional and pooling layers, was developed to analyze ECG signals.
- Data from 855 patients (555 with CKD) with hyperkalemia events were used, with ECGs matched to electrolyte tests within 2 hours.
- The model was trained and validated on 2-second ECG segments, with performance evaluated across multiple leads (I, II, V1-V6).
Main Results:
- The noninvasive screening tool achieved high performance, with F1 scores of 100% (training), 96% (validation), and 95% (test set).
- Lead II of the single-lead ECG demonstrated the highest performance in detecting hyperkalemia.
- The deep learning model effectively captured cardiac rhythm complexities for serum potassium level estimation.
Conclusions:
- A novel, noninvasive method for hyperkalemia screening using single-lead ECG and deep learning was successfully developed.
- This tool can serve as a valuable aid in emergency medicine for hyperkalemia assessment.
- The findings support the potential of ECG-based AI for real-time patient monitoring.
Background:
Hyperkalemia monitoring is very important in patients with chronic kidney disease (CKD) in emergency medicine. Currently, blood testing is regarded as the standard way to diagnose hyperkalemia (ie, using serum potassium levels). Therefore, an alternative and noninvasive method is required for real-time monitoring of hyperkalemia in the emergency medicine department.
Objective:
This study aimed to propose a novel method for noninvasive screening of hyperkalemia using a single-lead electrocardiogram (ECG) based on a deep learning model.
Methods:
For this study, 2958 patients with hyperkalemia events from July 2009 to June 2019 were enrolled at 1 regional emergency center, of which 1790 were diagnosed with chronic renal failure before hyperkalemic events. Patients who did not have biochemical electrolyte tests corresponding to the original 12-lead ECG signal were excluded. We used data from 855 patients (555 patients with CKD, and 300 patients without CKD). The 12-lead ECG signal was collected at the time of the hyperkalemic event, prior to the event, and after the event for each patient. All 12-lead ECG signals were matched with an electrolyte test within 2 hours of each ECG to form a data set. We then analyzed the ECG signals with a duration of 2 seconds and a segment composed of 1400 samples. The data set was randomly divided into the training set, validation set, and test set according to the ratio of 6:2:2 percent. The proposed noninvasive screening tool used a deep learning model that can express the complex and cyclic rhythm of cardiac activity. The deep learning model consists of convolutional and pooling layers for noninvasive screening of the serum potassium level from an ECG signal. To extract an optimal single-lead ECG, we evaluated the performances of the proposed deep learning model for each lead including lead I, II, and V1-V6.
Results:
The proposed noninvasive screening tool using a single-lead ECG shows high performances with F1 scores of 100%, 96%, and 95% for the training set, validation set, and test set, respectively. The lead II signal was shown to have the highest performance among the ECG leads.
Conclusions:
We developed a novel method for noninvasive screening of hyperkalemia using a single-lead ECG signal, and it can be used as a helpful tool in emergency medicine.
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